Conventional radionuclide imaging of autonomic function in heart failure

Arnold F. Jacobson, Jagat Narula

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Conventional nuclear imaging with single-photon emitting radionuclides can be used for qualitative and quantitative assessment of cardiac autonomic function in patients with heart failure. Status of sympathetic innervation can be assessed using [ 123 I]-metaiodobenzylguanidine ([ 123 I]-MIBG), an analogue of norepinephrine. Reduced myocardial [ 123 I]-MIBG uptake is common in heart failure patients, and the severity of global and regional abnormalities is indicative of the level of risk for mortality and occurrence of ventricular arrhythmias. [ 123 I]-MIBG imaging can identify early damage from cardiotoxic chemotherapy and early evidence of reinnervation in transplanted hearts. The extent of [ 123 I]-MIBG tomographic defects provides an indicator of the likelihood of appropriate implantable cardioverter-defibrillator (ICD) activation and may be useful in assessment of patients being considered for these devices. In the future, [ 123 I]-MIBG imaging may provide a non-invasive means to evaluate the effectiveness of heart failure treatments that reduce autonomic nervous system imbalances common in heart failure patients.

Original languageEnglish
Title of host publicationAutonomic Innervation of the Heart
Subtitle of host publicationRole of Molecular Imaging
PublisherSpringer Berlin Heidelberg
Number of pages26
ISBN (Electronic)9783662450741
ISBN (Print)9783662450734
StatePublished - 1 Jan 2015


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