Conventional nuclear imaging with single-photon emitting radionuclides can be used for qualitative and quantitative assessment of cardiac autonomic function in patients with heart failure. Status of sympathetic innervation can be assessed using [ 123 I]-metaiodobenzylguanidine ([ 123 I]-MIBG), an analogue of norepinephrine. Reduced myocardial [ 123 I]-MIBG uptake is common in heart failure patients, and the severity of global and regional abnormalities is indicative of the level of risk for mortality and occurrence of ventricular arrhythmias. [ 123 I]-MIBG imaging can identify early damage from cardiotoxic chemotherapy and early evidence of reinnervation in transplanted hearts. The extent of [ 123 I]-MIBG tomographic defects provides an indicator of the likelihood of appropriate implantable cardioverter-defibrillator (ICD) activation and may be useful in assessment of patients being considered for these devices. In the future, [ 123 I]-MIBG imaging may provide a non-invasive means to evaluate the effectiveness of heart failure treatments that reduce autonomic nervous system imbalances common in heart failure patients.
|Title of host publication||Autonomic Innervation of the Heart|
|Subtitle of host publication||Role of Molecular Imaging|
|Publisher||Springer Berlin Heidelberg|
|Number of pages||26|
|State||Published - 1 Jan 2015|