Controlling neuropathic pain in HIV

Susama Verma, Lydia Estanislao, Letty Mintz, David Simpson

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Neuropathic pain is associated with numerous systemic illnesses, including HIV infection. The diagnosis and management of peripheral neuropathy presents diagnostic and therapeutic challenges. Among various forms of HIV-associated peripheral neuropathies, distal symmetrical polyneuropathy (DSP) is the most common. DSP may be caused or exacerbated by neurotoxic antiretrovirals, particularly the dideoxynucleoside analogues (d-drugs). Selection of appropriate pharmacologic intervention for peripheral neuropathy should be based on efficacy, safety, ease of administration, and cost. We review treatment options for painful HIV neuropathy, including experimental agents studied in recent and ongoing clinical trials.

Original languageEnglish
Pages (from-to)237-242
Number of pages6
JournalCurrent Infectious Disease Reports
Issue number3
StatePublished - Jun 2004


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