TY - JOUR
T1 - Control of virus infection by tumour suppressors
AU - Muñoz-Fontela, César
AU - García, María A.
AU - Collado, Manuel
AU - Marcos-Villar, Laura
AU - Gallego, Pedro
AU - Esteban, Mariano
AU - Rivas, Carmen
N1 - Funding Information:
M.E. is funded by the Spanish Ministry of Education and Science (BIO2005-06264) and Fundación Marcelino Botín. C.R. is funded by the Spanish Ministry of Education and Science (BIO2005-00599) and Fundación de Investigación Médica Mutua Madrileña. M.C. is an investigator of the Ramon y Cajal Programme.
PY - 2007/6
Y1 - 2007/6
N2 - An increasing number of tumour suppressor genes are induced by interferons (IFNs) and may play an important role in the control of cell proliferation induced by this cytokine. In addition, pathways triggered by both tumour suppressors and IFN converge as common targets for non-related tumour viruses. The inhibition of the IFN response by animal viruses is explained by the fundamental role that IFN plays to control virus infection. However, the reasons why many viruses, including those that do not require the replication of the host, target tumour suppressor pathways are varied and are still under investigation. Here we review those findings that support that tumour suppressors may have a role in the control of virus infection.
AB - An increasing number of tumour suppressor genes are induced by interferons (IFNs) and may play an important role in the control of cell proliferation induced by this cytokine. In addition, pathways triggered by both tumour suppressors and IFN converge as common targets for non-related tumour viruses. The inhibition of the IFN response by animal viruses is explained by the fundamental role that IFN plays to control virus infection. However, the reasons why many viruses, including those that do not require the replication of the host, target tumour suppressor pathways are varied and are still under investigation. Here we review those findings that support that tumour suppressors may have a role in the control of virus infection.
UR - https://www.scopus.com/pages/publications/34447329573
U2 - 10.1093/carcin/bgm048
DO - 10.1093/carcin/bgm048
M3 - Review article
C2 - 17347139
AN - SCOPUS:34447329573
SN - 0143-3334
VL - 28
SP - 1140
EP - 1144
JO - Carcinogenesis
JF - Carcinogenesis
IS - 6
ER -