Control of surface mineralization using collagen fibrils

Weidong Tong, Steven J. Eppell

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Surface structure in the form of roughness and organized patterning can affect osteoblastic adhesion and proliferation. This study investigates the effect of reconstituted collagen fibrils on the deposition pattern of a homogeneous inorganic mineral (sodium chloride). The patterns were monitored from nanometer to millimeter scales using atomic force and light microscopies. Initially, mineral deposits formed blocks following the contour of the collagen fibrils. At later times, dendritic structures formed. This demonstrates that collagen fibrils can affect the surface deposition pattern of saline minerals. It is also shown that collagen fibril diameter and the stoichiometry of the inorganic and organic phases effect the surface distribution of minerals.

Original languageEnglish
Pages (from-to)346-353
Number of pages8
JournalJournal of Biomedical Materials Research
Issue number3
StatePublished - 5 Sep 2002
Externally publishedYes


  • Atomic force microscopy
  • Collagen
  • Mineralization
  • Orthopedic biomaterial
  • Osteoblast


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