Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers

Keyphrases

• Endothelial Cells 100%
• Endocytosis 100%
• Intercellular Adhesion molecule-1 (ICAM-1) 100%
• Size-and-shape 100%
• Therapeutic Enzymes 100%
• Targeted Delivery 100%
• Endothelial Targeting 100%
• Targeted Carrier 100%
• Intracellular Delivery 100%
• Drug Delivery 66%
• Vasculature 33%
• Rational Design 33%
• Lysosome 33%
• Intracellular Effects 33%
• Endothelium 33%
• Lysosomal Storage Disease 33%
• Long Half-life 33%
• Drug Target 33%
• Targeted Therapeutics 33%
• Residency 33%
• Enzyme Replacement Therapy 33%
• Cell Adhesion Molecules 33%
• Intracellular Trafficking 33%
• Acid Sphingomyelinase 33%
• Catalase 33%
• Membrane Glycoproteins 33%
• Target Specificity 33%
• Biomedical Applications 33%
• Clathrin-mediated Endocytosis 33%
• ICAM 33%
• Antioxidant Protection 33%
• Micron-sized 33%
• Caveolae-mediated Endocytosis 33%
• Submicron 33%
• Shape Sphere 33%
• High Targeting 33%
• Submicron Size 33%
• Lysosomal Transport 33%
• Polymeric Drug Carrier 33%
• Geometrical Influence 33%
• Elliptical Disks 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Intercellular Adhesion Molecule 1 100%
• Enzymes 100%
• Glycoprotein 50%
• Antioxidant 50%
• Sphingomyelin Phosphodiesterase 50%
• Catalase 50%
• Drug Delivery System 50%
• Lysosome Storage Disease 50%
• Clathrin 50%
• Polymer Carrier 50%
• Cell Adhesion Proteins 50%

Biochemistry, Genetics and Molecular Biology

• Enzyme 100%
• Endocytosis 100%
• Intercellular Adhesion Molecule 100%
• Glycoprotein 25%
• Lysosome 25%
• Clathrin 25%
• Vascularization 25%
• Intracellular Trafficking 25%
• Acid Sphingomyelinase 25%
• Sphingomyelin Phosphodiesterase 25%
• Drug Targeting 25%
• Catalase 25%
• Lysosomal Storage Disease 25%
• Cell Adhesion Proteins 25%
• Half-Life 25%