Contrast-induced acute kidney injury

Rishi Chandiramani, Davide Cao, Johny Nicolas, Roxana Mehran

Research output: Contribution to journalReview articlepeer-review

58 Scopus citations


Although major advancements in the field of cardiology have allowed for an increasing number of patients to undergo minimally invasive imaging and interventional procedures, contrast-induced acute kidney injury (CI-AKI) continues to be a dreaded complication among patients receiving intravascular contrast media. CI-AKI is characterized by progressive decline in kidney function within a few days of contrast medium administration. Physiological changes resulting from the direct nephrotoxic effect of contrast media on tubular epithelial cells and release of vasoactive molecules have been implicated in creating a state of increased oxidative stress and subsequent ischemic renal cell injury. Over the last several years, preventive strategies involving intravenous hydration, pharmaceutical agents and renal replacement therapies have resulted in lower rates of CI-AKI. However, due to the evolving paradigm of diagnostic and therapeutic interventions, several unanswered questions remain. This review highlights the epidemiology, pathogenesis and preventive strategies of CI-AKI.

Original languageEnglish
Pages (from-to)209-217
Number of pages9
JournalCardiovascular Intervention and Therapeutics
Issue number3
StatePublished - 1 Jul 2020


  • Acute kidney injury
  • Contrast
  • Nephropathy


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