Continuous lymphoid cell lines with characteristics of B cells (bone marrow derived), lacking the Epstein Barr virus genome and derived from three human lymphomas

G. Klein, T. Lindahl, M. Jondal, W. Leibold, J. Menézes, K. Nilsson, C. Sundström

Research output: Contribution to journalArticlepeer-review

267 Scopus citations

Abstract

Three exceptional cell lines were tested for the presence of the Epstein Barr virus genome by nucleic acid hybridization (complementary RNA DNA) and Epstein Barr virus determined nuclear antigen tests. Two lines were derived from Swedish lymphoma cases and one from an African Burkitt like lymphoma biopsy that was negative for Epstein Barr virus DNA and the virus determined nuclear antigen. All three lines apparently lacked the viral genome. Two of the three lines clearly had characteristics of B cells (bone marrow derived).

Original languageEnglish
Pages (from-to)3283-3286
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume71
Issue number8
DOIs
StatePublished - 1974
Externally publishedYes

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