Continuous lines of basophil/mast cells derived from normal mouse bone marrow

Kenji Nagao, Kenjiro Yokoro, Stuart A. Aaronson

Research output: Contribution to journalArticlepeer-review

99 Scopus citations

Abstract

Nonadherent tissue culture cell lines were established from normal bone marrow of a variety of mouse strains. The lines possessed morphological and histochemical markers of the basophil/mast cell and contained committed stem cells for metachromatic cells. Their derivation from normal marrow and their lack of tumorigenicity despite long-term culture makes these cell lines potentially important for studies of the mechanisms of allergic reactions and inflammation as well as the differentiation pathways involving this subset of hematopoietic cells.

Original languageEnglish
Pages (from-to)333-335
Number of pages3
JournalScience
Volume212
Issue number4492
DOIs
StatePublished - 1981
Externally publishedYes

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