Contemporary outcomes with the latest 1000 cases of multifetal pregnancy reduction (MPR)

Joanne Stone, Lauren Ferrara, Jacqueline Kamrath, Joelle Getrajdman, Richard Berkowitz, Erin Moshier, Keith Eddleman

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


Objective: This study was undertaken to report on the outcome of multifetal pregnancy reduction in the most up-to-date largest single center experience with this procedure, and compare the outcome to the first 1000 cases performed at the same institution. Study Design: 1000 consecutive cases of multifetal pregnancy reduction performed at the Mount Sinai Medical Center between the years 1999-2006 were identified. Pregnancy outcomes were retrieved from a large database as well as chart review. Differences in means and proportions were evaluated by analysis of variance, chi-square, Cochran-Armitage test for trend or 2-tailed Fisher exact test as appropriate. Results: Outcomes were available on 841 cases, for a follow-up rate of 84.1%; 95.2% of patients delivered after 24 weeks, for a complete loss rate of 4.7%. There was a significant trend toward decreasing loss rates with decreasing starting numbers. Mean gestational age at delivery was later, and birthweights greater, for reduction to singletons vs twins. Conclusion: Loss rates after multifetal pregnancy reduction have remained stable at 4.7%. The lowest loss rate occurred in the patients reducing from twins to a singleton (2.1%). Reduction to a singleton was also associated with higher birthweights and lower rates of preterm deliveries.

Original languageEnglish
Pages (from-to)406.e1-406.e4
JournalAmerican Journal of Obstetrics and Gynecology
Issue number4
StatePublished - Oct 2008


  • fetal reduction
  • multifetal pregnancy
  • outcomes


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