Contemplating genetic feedback regarding lung cancer susceptibility

James A. Shepperd; Corinne A. Novell; Suzanne C. O'Neill; Sharron L. Docherty; Saskia C. Sanderson; Colleen M. McBride; Isaac M. Lipkus

doi:10.1007/s12160-013-9561-z

Contemplating genetic feedback regarding lung cancer susceptibility

James A. Shepperd, Corinne A. Novell, Suzanne C. O'Neill, Sharron L. Docherty, Saskia C. Sanderson, Colleen M. McBride, Isaac M. Lipkus

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5 Scopus citations

Abstract

Background and Purpose We examined three theoretical models (self-enhancement theory, consistency theory, and a combined model) for understanding how expectations and test result favorability influence smokers' desire for a retest following hypothetical genetic test results. Method College smokers (N =128) read a brochure describing a biomarker for lung cancer (the GSTM1 gene) then reported whether they thought they had the gene (indicating lower lung cancer risk) or were missing the gene (indicating higher lung cancer risk). Participants then reported whether they would get retested if they received favorable GSTM1 results versus unfavorable GSTM1 results. Results Participants were most likely to want a retest, suggesting rejection of the results, if they expected favorable news yet received unfavorable news. Conclusion The findings supported the combined model such that smokers expressed greatest interest in a retest when they imagined genetic risk feedback that challenges both enhancement and consistency motives.

Original language	English
Pages (from-to)	395-403
Number of pages	9
Journal	Annals of Behavioral Medicine
Volume	47
Issue number	3
DOIs	https://doi.org/10.1007/s12160-013-9561-z
State	Published - Jun 2014

Keywords

Consistency theory
Expectations
Genes
Lung cancer
Self-enhancement theory

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@article{f324240530d8413aa78790eb45402ee7,

title = "Contemplating genetic feedback regarding lung cancer susceptibility",

abstract = "Background and Purpose We examined three theoretical models (self-enhancement theory, consistency theory, and a combined model) for understanding how expectations and test result favorability influence smokers' desire for a retest following hypothetical genetic test results. Method College smokers (N =128) read a brochure describing a biomarker for lung cancer (the GSTM1 gene) then reported whether they thought they had the gene (indicating lower lung cancer risk) or were missing the gene (indicating higher lung cancer risk). Participants then reported whether they would get retested if they received favorable GSTM1 results versus unfavorable GSTM1 results. Results Participants were most likely to want a retest, suggesting rejection of the results, if they expected favorable news yet received unfavorable news. Conclusion The findings supported the combined model such that smokers expressed greatest interest in a retest when they imagined genetic risk feedback that challenges both enhancement and consistency motives.",

keywords = "Consistency theory, Expectations, Genes, Lung cancer, Self-enhancement theory",

author = "Shepperd, {James A.} and Novell, {Corinne A.} and O'Neill, {Suzanne C.} and Docherty, {Sharron L.} and Sanderson, {Saskia C.} and McBride, {Colleen M.} and Lipkus, {Isaac M.}",

note = "Funding Information: Acknowledgments This research was funded by a grant from the National Cancer Institute (R01 CA121922-01A2), by an Intergovernmental Personnel Act Fellowship from the National Cancer Institute to James A. Shepperd, and by a grant to Suzanne C. O'Neill from the American Cancer Society (MRSG CPPB-10-110-01). We thank Greg Webster for assistance with the data analysis.",

year = "2014",

month = jun,

doi = "10.1007/s12160-013-9561-z",

language = "English",

volume = "47",

pages = "395--403",

journal = "Annals of Behavioral Medicine",

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publisher = "Oxford University Press",

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T1 - Contemplating genetic feedback regarding lung cancer susceptibility

AU - Shepperd, James A.

AU - Novell, Corinne A.

AU - O'Neill, Suzanne C.

AU - Docherty, Sharron L.

AU - Sanderson, Saskia C.

AU - McBride, Colleen M.

AU - Lipkus, Isaac M.

N1 - Funding Information: Acknowledgments This research was funded by a grant from the National Cancer Institute (R01 CA121922-01A2), by an Intergovernmental Personnel Act Fellowship from the National Cancer Institute to James A. Shepperd, and by a grant to Suzanne C. O'Neill from the American Cancer Society (MRSG CPPB-10-110-01). We thank Greg Webster for assistance with the data analysis.

PY - 2014/6

Y1 - 2014/6

N2 - Background and Purpose We examined three theoretical models (self-enhancement theory, consistency theory, and a combined model) for understanding how expectations and test result favorability influence smokers' desire for a retest following hypothetical genetic test results. Method College smokers (N =128) read a brochure describing a biomarker for lung cancer (the GSTM1 gene) then reported whether they thought they had the gene (indicating lower lung cancer risk) or were missing the gene (indicating higher lung cancer risk). Participants then reported whether they would get retested if they received favorable GSTM1 results versus unfavorable GSTM1 results. Results Participants were most likely to want a retest, suggesting rejection of the results, if they expected favorable news yet received unfavorable news. Conclusion The findings supported the combined model such that smokers expressed greatest interest in a retest when they imagined genetic risk feedback that challenges both enhancement and consistency motives.

AB - Background and Purpose We examined three theoretical models (self-enhancement theory, consistency theory, and a combined model) for understanding how expectations and test result favorability influence smokers' desire for a retest following hypothetical genetic test results. Method College smokers (N =128) read a brochure describing a biomarker for lung cancer (the GSTM1 gene) then reported whether they thought they had the gene (indicating lower lung cancer risk) or were missing the gene (indicating higher lung cancer risk). Participants then reported whether they would get retested if they received favorable GSTM1 results versus unfavorable GSTM1 results. Results Participants were most likely to want a retest, suggesting rejection of the results, if they expected favorable news yet received unfavorable news. Conclusion The findings supported the combined model such that smokers expressed greatest interest in a retest when they imagined genetic risk feedback that challenges both enhancement and consistency motives.

KW - Consistency theory

KW - Expectations

KW - Genes

KW - Lung cancer

KW - Self-enhancement theory

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Contemplating genetic feedback regarding lung cancer susceptibility

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Keywords

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