TY - JOUR
T1 - Consumption of Yoghurt and Other Dairy Products and Risk of Colorectal Cancer in Iran
T2 - The IROPICAN Study
AU - Collatuzzo, Giulia
AU - Seyyedsalehi, Monireh Sadat
AU - Rezaeianzadeh, Abbas
AU - Marzban, Maryam
AU - Rashidian, Hamideh
AU - Hadji, Maryam
AU - Kamangar, Farin
AU - Etemadi, Arash
AU - Pukkala, Eero
AU - Zendehdel, Kazem
AU - Boffetta, Paolo
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/6/1
Y1 - 2022/6/1
N2 - Background: There is evidence of an inverse association between yoghurt intake and risk of colorectal cancer (CRC). We aimed at investigating the association between the intake of yoghurt and other dairy foods consumed in Iran and CRC risk. Methods: Our analysis included 4070 subjects within the IROPICAN (Iran Study of Opium and Cancer) study. Detailed information was collected by the use of validated questionnaires. We estimated adjusted odds ratios (OR) and 95% confidence intervals (CI) for the association between the intake of total dairy products, and, separately, of yo-ghurt, milk, cheese, kashk, dough, cream, ice cream, and other milk products, and CRC using un-conditional logistic regression analyses. The intake was categorized in tertiles. Results: Overall, we analyzed 865 cases and 3205 controls. Total dairy products intake was not associated with CRC. The OR for one tertile increase (OR_T) in yoghurt intake was 0.97 (95% CI 0.87–1.08) for CRC and 0.66 (95% CI 0.52–0.84) for proximal colon cancer. Cream intake was associated with CRC (OR_T3 = 1.33, 95% CI 1.08–1.64), colon (OR_T3 = 1.37, 95% CI 1.03–1.81), and proximal cancer (OR_T3 = 1.29, 95% CI 1.04–1.61). The OR of distal colon cancer for ice cream intake was 0.59 (95% CI 0.43–0.82). Other dairy products were not associated with CRC risk.
AB - Background: There is evidence of an inverse association between yoghurt intake and risk of colorectal cancer (CRC). We aimed at investigating the association between the intake of yoghurt and other dairy foods consumed in Iran and CRC risk. Methods: Our analysis included 4070 subjects within the IROPICAN (Iran Study of Opium and Cancer) study. Detailed information was collected by the use of validated questionnaires. We estimated adjusted odds ratios (OR) and 95% confidence intervals (CI) for the association between the intake of total dairy products, and, separately, of yo-ghurt, milk, cheese, kashk, dough, cream, ice cream, and other milk products, and CRC using un-conditional logistic regression analyses. The intake was categorized in tertiles. Results: Overall, we analyzed 865 cases and 3205 controls. Total dairy products intake was not associated with CRC. The OR for one tertile increase (OR_T) in yoghurt intake was 0.97 (95% CI 0.87–1.08) for CRC and 0.66 (95% CI 0.52–0.84) for proximal colon cancer. Cream intake was associated with CRC (OR_T3 = 1.33, 95% CI 1.08–1.64), colon (OR_T3 = 1.37, 95% CI 1.03–1.81), and proximal cancer (OR_T3 = 1.29, 95% CI 1.04–1.61). The OR of distal colon cancer for ice cream intake was 0.59 (95% CI 0.43–0.82). Other dairy products were not associated with CRC risk.
KW - colon
KW - colorectal cancer
KW - dairy products
KW - diet
KW - nutrition epidemiology
KW - yoghurt
UR - http://www.scopus.com/inward/record.url?scp=85132043095&partnerID=8YFLogxK
U2 - 10.3390/nu14122506
DO - 10.3390/nu14122506
M3 - Article
C2 - 35745234
AN - SCOPUS:85132043095
SN - 2072-6643
VL - 14
JO - Nutrients
JF - Nutrients
IS - 12
M1 - 2506
ER -