Construction and characterisation of a heparan sulphate heptasaccharide microarray

Jianhong Yang; Po Hung Hsieh; Xinyue Liu; Wen Zhou; Xing Zhang; Jing Zhao; Yongmei Xu; Fuming Zhang; Robert J. Linhardt; Jian Liu

doi:10.1039/c6cc08204a

Construction and characterisation of a heparan sulphate heptasaccharide microarray

Jianhong Yang
, Po Hung Hsieh
, Xinyue Liu
, Wen Zhou
, Xing Zhang
, Jing Zhao
, Yongmei Xu
, Fuming Zhang
, Robert J. Linhardt
, Jian Liu

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

A targeted heptasaccharide library was synthesised to prepare a heparan sulphate (HS) microarray. The array was probed with two glycan-binding proteins, HS 3-O-sulphotransferase 1 and antithrombin, demonstrating the binding selectivity between HS and proteins. The HS microarray technique will accelerate the understanding of the structure and function relationships of HS.

Original language	English
Pages (from-to)	1743-1746
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	10
DOIs	https://doi.org/10.1039/c6cc08204a
State	Published - 2017
Externally published	Yes

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10.1039/c6cc08204a

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title = "Construction and characterisation of a heparan sulphate heptasaccharide microarray",

abstract = "A targeted heptasaccharide library was synthesised to prepare a heparan sulphate (HS) microarray. The array was probed with two glycan-binding proteins, HS 3-O-sulphotransferase 1 and antithrombin, demonstrating the binding selectivity between HS and proteins. The HS microarray technique will accelerate the understanding of the structure and function relationships of HS.",

author = "Jianhong Yang and Hsieh, \{Po Hung\} and Xinyue Liu and Wen Zhou and Xing Zhang and Jing Zhao and Yongmei Xu and Fuming Zhang and Linhardt, \{Robert J.\} and Jian Liu",

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doi = "10.1039/c6cc08204a",

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pages = "1743--1746",

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AU - Yang, Jianhong

AU - Hsieh, Po Hung

AU - Liu, Xinyue

AU - Zhou, Wen

AU - Zhang, Xing

AU - Zhao, Jing

AU - Xu, Yongmei

AU - Zhang, Fuming

AU - Linhardt, Robert J.

AU - Liu, Jian

PY - 2017

Y1 - 2017

N2 - A targeted heptasaccharide library was synthesised to prepare a heparan sulphate (HS) microarray. The array was probed with two glycan-binding proteins, HS 3-O-sulphotransferase 1 and antithrombin, demonstrating the binding selectivity between HS and proteins. The HS microarray technique will accelerate the understanding of the structure and function relationships of HS.

AB - A targeted heptasaccharide library was synthesised to prepare a heparan sulphate (HS) microarray. The array was probed with two glycan-binding proteins, HS 3-O-sulphotransferase 1 and antithrombin, demonstrating the binding selectivity between HS and proteins. The HS microarray technique will accelerate the understanding of the structure and function relationships of HS.

UR - https://www.scopus.com/pages/publications/85010992188

U2 - 10.1039/c6cc08204a

DO - 10.1039/c6cc08204a

M3 - Article

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AN - SCOPUS:85010992188

SN - 1359-7345

VL - 53

SP - 1743

EP - 1746

JO - Chemical Communications

JF - Chemical Communications

IS - 10

ER -

Construction and characterisation of a heparan sulphate heptasaccharide microarray

Abstract

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