Consideration of use of phenothiazines in particular trifluorperazine for epidermal growth factor receptor associated cancers

Richard E. Kast, Eric Lewin Altschuler

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Papers from a generation ago suggested that phenothiazines - in particular trifluorperazine (Stelazine) a medicinal approved by the FDA and still commonly used for schizophrenia - downregulate the epidermal growth factor receptor. As numerous cancers - e.g., colon cancer, breast cancer, pancreatic cancer and glioblastoma - are dependent on signaling via this receptor, we here suggest that phenothiazines such as trifluorperazine be considered for use in epidermal growth factor receptor associated cancers.

Original languageEnglish
Pages (from-to)1074-1075
Number of pages2
JournalMedical Hypotheses
Volume69
Issue number5
DOIs
StatePublished - 2007
Externally publishedYes

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