Consensus opinion of US neurologists on practice patterns in RIS, CIS, and RRMS

Carlo Tornatore, J. Theodore Phillips, Omar Khan, Aaron E. Miller, Mark Hughes

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


Purpose of review: To assess current practice patterns of US neurologists in patients with radiologically isolated syndrome (RIS), clinically isolated syndrome (CIS), and relapsing-remitting multiple sclerosis (RRMS) using case-based Web surveys. Recent findings: We identified a total of 47 points of consensus (≥75% agreement) with regard to diagnosis, treatment, and monitoring of RIS, CIS, and RRMS. Current US treatment consensus patterns emphasize (1) MRI in multiple sclerosis (MS) diagnosis and subsequent treatment decisions, (2) treatment of early disease, (3) aggressive initial treatment of highly active MS, and (4) close patient monitoring for clinical response and adverse effects of disease-modifying drugs. Summary: These findings may offer insights into harmonizing MS care and represent the first steps in potentially establishing a more uniform approach to the treatment of patients with MS in the United States without compromising the need for individual treatment for each patient.

Original languageEnglish
Pages (from-to)329-338
Number of pages10
JournalNeurology: Clinical Practice
Issue number4
StatePublished - 1 Aug 2016


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