Connexins and the heart

Glenn I. Fishman

doi:10.1016/1050-1738(92)90004-C

Connexins and the heart

Glenn I. Fishman

Research output: Contribution to journal › Short survey › peer-review

8 Scopus citations

Abstract

Gap junctions are specialized regions of adjoining cell membranes composed of numerous intercellular low-resistance channels. In the heart, these channels electrotonically couple adjacent myocytes and synchronize the cardiac action potential. Signaling through gap junction channels may also influence embryogenesis and development. Recent studies have identified the connexin gene family whose protein products assemble to form gap junction channels. Studies of connexin gene expression and function are providing new insights into the behavior of gap junction channels in the heart.

Original language	English
Pages (from-to)	50-55
Number of pages	6
Journal	Trends in Cardiovascular Medicine
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/1050-1738(92)90004-C
State	Published - 1992
Externally published	Yes

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@article{5ed4adceeb654249ab1fd7030c621806,

title = "Connexins and the heart",

abstract = "Gap junctions are specialized regions of adjoining cell membranes composed of numerous intercellular low-resistance channels. In the heart, these channels electrotonically couple adjacent myocytes and synchronize the cardiac action potential. Signaling through gap junction channels may also influence embryogenesis and development. Recent studies have identified the connexin gene family whose protein products assemble to form gap junction channels. Studies of connexin gene expression and function are providing new insights into the behavior of gap junction channels in the heart.",

author = "Fishman, {Glenn I.}",

note = "Funding Information: The studies reported here were carried out in the laboratories of Leslie A. Ieinwand and David C. Spray, whose great help and generosity the author wishes to acknowledge. The author also thanks Alonso Moreno for his continuing collaboration. This work was supported in part by National Institutes of Health Physician-scientist Award lKllHL02391 and a grant-in-aid from the American Heart Association, New York City Affiliate.",

year = "1992",

doi = "10.1016/1050-1738(92)90004-C",

language = "English",

volume = "2",

pages = "50--55",

journal = "Trends in Cardiovascular Medicine",

issn = "1050-1738",

publisher = "Elsevier Inc.",

number = "2",

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TY - JOUR

T1 - Connexins and the heart

AU - Fishman, Glenn I.

N1 - Funding Information: The studies reported here were carried out in the laboratories of Leslie A. Ieinwand and David C. Spray, whose great help and generosity the author wishes to acknowledge. The author also thanks Alonso Moreno for his continuing collaboration. This work was supported in part by National Institutes of Health Physician-scientist Award lKllHL02391 and a grant-in-aid from the American Heart Association, New York City Affiliate.

PY - 1992

Y1 - 1992

N2 - Gap junctions are specialized regions of adjoining cell membranes composed of numerous intercellular low-resistance channels. In the heart, these channels electrotonically couple adjacent myocytes and synchronize the cardiac action potential. Signaling through gap junction channels may also influence embryogenesis and development. Recent studies have identified the connexin gene family whose protein products assemble to form gap junction channels. Studies of connexin gene expression and function are providing new insights into the behavior of gap junction channels in the heart.

AB - Gap junctions are specialized regions of adjoining cell membranes composed of numerous intercellular low-resistance channels. In the heart, these channels electrotonically couple adjacent myocytes and synchronize the cardiac action potential. Signaling through gap junction channels may also influence embryogenesis and development. Recent studies have identified the connexin gene family whose protein products assemble to form gap junction channels. Studies of connexin gene expression and function are providing new insights into the behavior of gap junction channels in the heart.

UR - http://www.scopus.com/inward/record.url?scp=0026504412&partnerID=8YFLogxK

U2 - 10.1016/1050-1738(92)90004-C

DO - 10.1016/1050-1738(92)90004-C

M3 - Short survey

AN - SCOPUS:0026504412

SN - 1050-1738

VL - 2

SP - 50

EP - 55

JO - Trends in Cardiovascular Medicine

JF - Trends in Cardiovascular Medicine

IS - 2

ER -

Connexins and the heart

Abstract

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