Congenital intractable diarrhea of infancy in Iraqi Jews

Rachel Straussberg, Rivka Shapiro, Jacob Amir, Anita Yonash, Avinoam Rachmel, William M. Bisset, Itzhak Varsano

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

We report on five patients who presented with intractable diarrhea starting during the first days of life. The patients belonged to four families of Iraqi Jewish origin. Autosomal recessive inheritance is suggested by parental consanguinity in three families and recurrence in another sib in one family. The patients were all born after uneventful pregnancy and labor, with birth weight in the normal range. There were no dysmorphic features. Three patients were breast fed. Diarrhea started between the first and eighth day of life. Diarrhea was of the secretory type. No pathogen was cultured from the stool. Jejunal biopsies performed on all patients ranged from normal to severe partial villous atrophy. The patients received different drug regimens with no beneficial effect and all are dependent on TPN. These findings and the common ethnic origin of the patients suggest that these patients have the same syndrome of congenital intractable diarrhea. No similar cases are known in other ethnic groups in Israel, suggesting a possibility of high gene frequency among the Jews of Iraqi origin.

Original languageEnglish
Pages (from-to)98-101
Number of pages4
JournalClinical Genetics
Volume51
Issue number2
DOIs
StatePublished - 1997
Externally publishedYes

Keywords

  • Autosomal recessive
  • Inheritance
  • Intractable diarrhea

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