Abstract
To the Editor: In Part I of their review on congenital adrenal hyperplasia (June 11 issue),1 White et al. discuss the steroidogenic enzymes and the clinical manifestations of disorders involving those enzymes; another detailed review has recently been published.2 The discussion by White et al. of the molecular genetics of 21-hydroxylase deficiency in Part II of their review (June 18 issue)3 is a bit more controversial. Their studies and those of most other groups have been similar: genomic DNA from patients with congenital adrenal hyperplasia was digested with the restriction endonuclease TaqI and analyzed by probing Southern blots with…
| Original language | English |
|---|---|
| Pages (from-to) | 1413-1415 |
| Number of pages | 3 |
| Journal | New England Journal of Medicine |
| Volume | 317 |
| Issue number | 22 |
| DOIs | |
| State | Published - 26 Nov 1987 |
| Externally published | Yes |