Confocal laser endomicroscopy for in vivo diagnosis of gastric intraepithelial neoplasia: A feasibility study

Zhen Li, Tao Yu, Xiu Li Zuo, Xiao Meng Gu, Cheng Jun Zhou, Rui Ji, Chang Qing Li, Peng Wang, Ting Guo Zhang, Khek Yu Ho, Yan Qing Li

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46 Scopus citations

Abstract

Background Confocal laser endomicroscopy (CLE) is a novel endoscopic modality that allows subsurface analysis of the gastric mucosa during ongoing endoscopy. Several studies have reported that this technique is of value in the diagnosis of premalignant lesions in the GI tract, but as yet no investigations have reported its application in the analysis of gastric intraepithelial neoplasia (GIN). Objective To assess the feasibility of CLE for the identification and grading of GIN. Design Prospective double-blind feasibility study. Setting Qilu Hospital, Shandong University, Jinan, China. Patients CLE images of 33 patients were first evaluated to establish the diagnostic criteria for gastric lesions. Eligible patients were then prospectively investigated by CLE using the newly established criteria. Interventions All endoscopically suspicious lesions were examined by CLE, and CLE diagnoses were compared with corresponding histopathologic results. Main Outcome Measurements Sensitivity, specificity, and positive and negative likelihood ratios of CLE diagnosis of biopsy-proven intraepithelial neoplasia by per-lesion analysis. Results The sensitivity, specificity, and positive and negative likelihood ratios of CLE diagnosis of GIN were 77.8%, 81.8%, 4.28, and 0.27, respectively. The mean κ value for interobserver agreement for the diagnosis of GIN was 0.70 among endoscopists and 0.71 between endoscopist and GI pathologist. Intraepithelial neoplasia score <5 differentiated high-grade from low-grade intraepithelial neoplasia with a sensitivity of 66.7% and a specificity of 88.0%. Limitations Nonrandomized single-center study, limited number of patients. Conclusions CLE is an acceptable and potentially useful technology for the identification and grading of GIN in vivo. The diagnostic accuracy needs to be improved.

Original languageEnglish
Pages (from-to)1146-1153
Number of pages8
JournalGastrointestinal Endoscopy
Volume72
Issue number6
DOIs
StatePublished - Dec 2010
Externally publishedYes

Keywords

  • Abbreviations
  • CI
  • CLE
  • Confidence interval
  • Confocal laser endomicroscopy
  • GIN
  • Gastric intraepithelial neoplasia
  • HGIN
  • High-grade intraepithelial neoplasia
  • INS
  • Intraepithelial neoplasia score
  • LGIN
  • Low-grade intraepithelial neoplasia
  • ROC

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