Confirming evidence for the clonal development and stem cell origin of philadelphia chromosome‐negative chronic myelogenous leukemia

Frederic J. Kaye; Vesna Najfeld; Jack Singer; Janet Cuttner; Philip J. Fialkow

doi:10.1002/ajh.2830170113

Confirming evidence for the clonal development and stem cell origin of philadelphia chromosome‐negative chronic myelogenous leukemia

Frederic J. Kaye
, Vesna Najfeld
, Jack Singer
, Janet Cuttner
, Philip J. Fialkow

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A 74‐year old woman with Ph¹‐negative chronic myelogenous leukemia (CML) and heterozygous for glucose‐6‐phosphate dehydrogenase (G6PD) was studied. Both A and B types of G6PD were found in skin. In contrast, white blood cells and platelets showed only a single G6PD type A. These results provide further evidence that Ph¹‐negative CML has a stem cell origin and develops clonally.

Original language	English
Pages (from-to)	93-96
Number of pages	4
Journal	American Journal of Hematology
Volume	17
Issue number	1
DOIs	https://doi.org/10.1002/ajh.2830170113
State	Published - Jul 1984

Keywords

Ph‐negative CML
clonal development
stem cell origin

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title = "Confirming evidence for the clonal development and stem cell origin of philadelphia chromosome‐negative chronic myelogenous leukemia",

abstract = "A 74‐year old woman with Ph1‐negative chronic myelogenous leukemia (CML) and heterozygous for glucose‐6‐phosphate dehydrogenase (G6PD) was studied. Both A and B types of G6PD were found in skin. In contrast, white blood cells and platelets showed only a single G6PD type A. These results provide further evidence that Ph1‐negative CML has a stem cell origin and develops clonally.",

keywords = "Ph‐negative CML, clonal development, stem cell origin",

author = "Kaye, \{Frederic J.\} and Vesna Najfeld and Jack Singer and Janet Cuttner and Fialkow, \{Philip J.\}",

year = "1984",

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T1 - Confirming evidence for the clonal development and stem cell origin of philadelphia chromosome‐negative chronic myelogenous leukemia

AU - Kaye, Frederic J.

AU - Najfeld, Vesna

AU - Singer, Jack

AU - Cuttner, Janet

AU - Fialkow, Philip J.

PY - 1984/7

Y1 - 1984/7

N2 - A 74‐year old woman with Ph1‐negative chronic myelogenous leukemia (CML) and heterozygous for glucose‐6‐phosphate dehydrogenase (G6PD) was studied. Both A and B types of G6PD were found in skin. In contrast, white blood cells and platelets showed only a single G6PD type A. These results provide further evidence that Ph1‐negative CML has a stem cell origin and develops clonally.

AB - A 74‐year old woman with Ph1‐negative chronic myelogenous leukemia (CML) and heterozygous for glucose‐6‐phosphate dehydrogenase (G6PD) was studied. Both A and B types of G6PD were found in skin. In contrast, white blood cells and platelets showed only a single G6PD type A. These results provide further evidence that Ph1‐negative CML has a stem cell origin and develops clonally.

KW - Ph‐negative CML

KW - clonal development

KW - stem cell origin

UR - https://www.scopus.com/pages/publications/0021237550

U2 - 10.1002/ajh.2830170113

DO - 10.1002/ajh.2830170113

M3 - Article

C2 - 6588750

AN - SCOPUS:0021237550

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SP - 93

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JO - American Journal of Hematology

JF - American Journal of Hematology

IS - 1

ER -

Confirming evidence for the clonal development and stem cell origin of philadelphia chromosome‐negative chronic myelogenous leukemia

Abstract

Keywords

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