Confirming evidence for the clonal development and stem cell origin of philadelphia chromosome‐negative chronic myelogenous leukemia

Frederic J. Kaye; Vesna Najfeld; Jack Singer; Janet Cuttner; Philip J. Fialkow

doi:10.1002/ajh.2830170113

Confirming evidence for the clonal development and stem cell origin of philadelphia chromosome‐negative chronic myelogenous leukemia

Frederic J. Kaye, Vesna Najfeld, Jack Singer, Janet Cuttner, Philip J. Fialkow

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A 74‐year old woman with Ph¹‐negative chronic myelogenous leukemia (CML) and heterozygous for glucose‐6‐phosphate dehydrogenase (G6PD) was studied. Both A and B types of G6PD were found in skin. In contrast, white blood cells and platelets showed only a single G6PD type A. These results provide further evidence that Ph¹‐negative CML has a stem cell origin and develops clonally.

Original language	English
Pages (from-to)	93-96
Number of pages	4
Journal	American Journal of Hematology
Volume	17
Issue number	1
DOIs	https://doi.org/10.1002/ajh.2830170113
State	Published - Jul 1984

Keywords

Ph‐negative CML
clonal development
stem cell origin

Access to Document

10.1002/ajh.2830170113

Cite this

@article{22b6c45fa4f147378f52027b4e66e6c9,

title = "Confirming evidence for the clonal development and stem cell origin of philadelphia chromosome‐negative chronic myelogenous leukemia",

abstract = "A 74‐year old woman with Ph1‐negative chronic myelogenous leukemia (CML) and heterozygous for glucose‐6‐phosphate dehydrogenase (G6PD) was studied. Both A and B types of G6PD were found in skin. In contrast, white blood cells and platelets showed only a single G6PD type A. These results provide further evidence that Ph1‐negative CML has a stem cell origin and develops clonally.",

keywords = "Ph‐negative CML, clonal development, stem cell origin",

author = "Kaye, {Frederic J.} and Vesna Najfeld and Jack Singer and Janet Cuttner and Fialkow, {Philip J.}",

year = "1984",

month = jul,

doi = "10.1002/ajh.2830170113",

language = "English",

volume = "17",

pages = "93--96",

journal = "American Journal of Hematology",

issn = "0361-8609",

publisher = "John Wiley and Sons Inc.",

number = "1",

}

TY - JOUR

T1 - Confirming evidence for the clonal development and stem cell origin of philadelphia chromosome‐negative chronic myelogenous leukemia

AU - Kaye, Frederic J.

AU - Najfeld, Vesna

AU - Singer, Jack

AU - Cuttner, Janet

AU - Fialkow, Philip J.

PY - 1984/7

Y1 - 1984/7

N2 - A 74‐year old woman with Ph1‐negative chronic myelogenous leukemia (CML) and heterozygous for glucose‐6‐phosphate dehydrogenase (G6PD) was studied. Both A and B types of G6PD were found in skin. In contrast, white blood cells and platelets showed only a single G6PD type A. These results provide further evidence that Ph1‐negative CML has a stem cell origin and develops clonally.

AB - A 74‐year old woman with Ph1‐negative chronic myelogenous leukemia (CML) and heterozygous for glucose‐6‐phosphate dehydrogenase (G6PD) was studied. Both A and B types of G6PD were found in skin. In contrast, white blood cells and platelets showed only a single G6PD type A. These results provide further evidence that Ph1‐negative CML has a stem cell origin and develops clonally.

KW - Ph‐negative CML

KW - clonal development

KW - stem cell origin

UR - http://www.scopus.com/inward/record.url?scp=0021237550&partnerID=8YFLogxK

U2 - 10.1002/ajh.2830170113

DO - 10.1002/ajh.2830170113

M3 - Article

C2 - 6588750

AN - SCOPUS:0021237550

SN - 0361-8609

VL - 17

SP - 93

EP - 96

JO - American Journal of Hematology

JF - American Journal of Hematology

IS - 1

ER -

Confirming evidence for the clonal development and stem cell origin of philadelphia chromosome‐negative chronic myelogenous leukemia

Abstract

Keywords

Access to Document

Fingerprint

Cite this