Concurrent chemotherapy and radiation therapy for inoperable locally advanced non-small-cell lung cancer

Kenneth E. Rosenzweig, Jorge E. Gomez

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

A 72-year-old man with a 40-pack-year tobacco history developed a cough and decreased exercise tolerance. A chest x-ray demonstrated a right-upper-lobe opacity. Chest computed tomography (CT) scan revealed a 2.5-cm mass in the right upper lobe with multiple mediastinal lymph node disease (Fig 1). A positron emission tomography (PET) scan confirmed the lung lesion and themediastinal lymphadenopathy without distantmetastases. Brain magnetic resonance imaging results were negative. The biopsy specimen revealed adenocarcinoma with no actionable mutations present. Cervical mediastinoscopy was positive for carcinoma in level 2, 3, 4R, and 7 lymph nodes; level 4L was negative. The patient's stage was T1bN2M0, stage IIIA. His medical history was significant for hyperlipidemia and hypothyroidism. He had smoked one pack a day for 40 years and had quit 15 years earlier. Physical examination was unrevealing, and the patient had an Eastern Cooperative Oncology Group performance status of 0. Because of the extent of lung cancer in the mediastinum, the patient's cancerwas deemed inoperable, and he was referred for consideration of concurrent chemotherapy and radiation.

Original languageEnglish
Pages (from-to)6-10
Number of pages5
JournalJournal of Clinical Oncology
Volume35
Issue number1
DOIs
StatePublished - 1 Jan 2017

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