TY - JOUR
T1 - Concordant and discordant associations between rheumatoid arthritis, systemic lupus erythematosus and ankylosing spondylitis based on all hospitalizations in Sweden between 1973 and 2004
AU - Sundquist, Kristina
AU - Martineus, J. C.
AU - Li, X.
AU - Hemminki, K.
AU - Sundquist, J.
N1 - Funding Information:
Funding: The National Institutes of Health (R01 HD052848-01 A1), The Swedish Research Council (K2005-27X-15428-01A), the Swedish Council for Working Life and Social Research (2006-0386 and 2007-1754), The Swedish Research Council Formas (2006-4255-6596-99 and 2007-1352) and the Stockholm County Council.
PY - 2008/8
Y1 - 2008/8
N2 - Objectives. To quantify the sibling risk of RA, SLE and AS. To analyse the concordant and discordant associations between RA, SLE and AS. Methods. Follow-up study of all individuals and their siblings born in or after 1932 and hospitalized for RA, SLE or AS between 1973 and 2004 (32 yrs). Data were retrieved from a comprehensive dataconstructed by using several national Swedish data registers, including the Total Population Register, the Swedish Hospital Discharge Register and the Multigeneration Register. Standardized incidence ratios (SIRs) were used to estimate sibling risks. Results. For males, the overall significant SIRs were 4.72, 4.35 and 4.14 for RA, SLE and AS, respectively, if a sibling was affected by any inflammatory disease. The corresponding significant SIRs for females were 4.12, 3.73 and 4.73. The concordant significant SIRs in siblings were 5.12, 17.02 and 17.14 for RA, SLE and AS, respectively. There were also discordant associations between RA and SLE, whereas AS was only associated with AS. Conclusions. This study was able objectively to quantify the sibling risk of RA, SLE and AS, which represents useful knowledge for clinicians and geneticists. The analysis of concordant and discordant associations may be useful in future studies aimed at finding specific genes associated with these diseases.
AB - Objectives. To quantify the sibling risk of RA, SLE and AS. To analyse the concordant and discordant associations between RA, SLE and AS. Methods. Follow-up study of all individuals and their siblings born in or after 1932 and hospitalized for RA, SLE or AS between 1973 and 2004 (32 yrs). Data were retrieved from a comprehensive dataconstructed by using several national Swedish data registers, including the Total Population Register, the Swedish Hospital Discharge Register and the Multigeneration Register. Standardized incidence ratios (SIRs) were used to estimate sibling risks. Results. For males, the overall significant SIRs were 4.72, 4.35 and 4.14 for RA, SLE and AS, respectively, if a sibling was affected by any inflammatory disease. The corresponding significant SIRs for females were 4.12, 3.73 and 4.73. The concordant significant SIRs in siblings were 5.12, 17.02 and 17.14 for RA, SLE and AS, respectively. There were also discordant associations between RA and SLE, whereas AS was only associated with AS. Conclusions. This study was able objectively to quantify the sibling risk of RA, SLE and AS, which represents useful knowledge for clinicians and geneticists. The analysis of concordant and discordant associations may be useful in future studies aimed at finding specific genes associated with these diseases.
KW - Ankylosing spondylitis
KW - Rheumatoid arthritis
KW - Siblings
KW - Sweden
KW - Systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=47849101668&partnerID=8YFLogxK
U2 - 10.1093/rheumatology/ken184
DO - 10.1093/rheumatology/ken184
M3 - Article
C2 - 18524808
AN - SCOPUS:47849101668
SN - 1462-0324
VL - 47
SP - 1199
EP - 1202
JO - Rheumatology
JF - Rheumatology
IS - 8
ER -