Concise synthesis of two natural triterpenoid saponins, oleanolic acid derivatives isolated from the roots of Pulsatilla chinensis

Qingchao Liu; Peng Wang; Lei Zhang; Tiantian Guo; Guokai Lv; Yingxia Li

doi:10.1016/j.carres.2009.05.011

Concise synthesis of two natural triterpenoid saponins, oleanolic acid derivatives isolated from the roots of Pulsatilla chinensis

Qingchao Liu, Peng Wang, Lei Zhang, Tiantian Guo, Guokai Lv, Yingxia Li

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The first synthesis of two natural triterpenoid saponins, which were isolated from the roots of Pulsatilla chinensis and exhibited excellent in vitro cytotoxic activity against HL-60 cells, was concisely achieved in a convergent approach. We employed an odourless 2-methyl-5-tert-butylphenyl (Mbp) thioglycoside and trichloroacetimidate donors in one-pot reaction as a key step.

Original language	English
Pages (from-to)	1276-1281
Number of pages	6
Journal	Carbohydrate Research
Volume	344
Issue number	11
DOIs	https://doi.org/10.1016/j.carres.2009.05.011
State	Published - 27 Jul 2009
Externally published	Yes

Keywords

HL-60 cells
Mbp thioglycoside
One-pot reaction
Trichloroacetimidates
Triterpenoid saponins

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10.1016/j.carres.2009.05.011

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title = "Concise synthesis of two natural triterpenoid saponins, oleanolic acid derivatives isolated from the roots of Pulsatilla chinensis",

abstract = "The first synthesis of two natural triterpenoid saponins, which were isolated from the roots of Pulsatilla chinensis and exhibited excellent in vitro cytotoxic activity against HL-60 cells, was concisely achieved in a convergent approach. We employed an odourless 2-methyl-5-tert-butylphenyl (Mbp) thioglycoside and trichloroacetimidate donors in one-pot reaction as a key step.",

keywords = "HL-60 cells, Mbp thioglycoside, One-pot reaction, Trichloroacetimidates, Triterpenoid saponins",

author = "Qingchao Liu and Peng Wang and Lei Zhang and Tiantian Guo and Guokai Lv and Yingxia Li",

note = "Funding Information: This work was financially supported by the Natural Science Foundation of China (30701046). ",

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AU - Liu, Qingchao

AU - Wang, Peng

AU - Zhang, Lei

AU - Guo, Tiantian

AU - Lv, Guokai

AU - Li, Yingxia

N1 - Funding Information: This work was financially supported by the Natural Science Foundation of China (30701046).

PY - 2009/7/27

Y1 - 2009/7/27

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AB - The first synthesis of two natural triterpenoid saponins, which were isolated from the roots of Pulsatilla chinensis and exhibited excellent in vitro cytotoxic activity against HL-60 cells, was concisely achieved in a convergent approach. We employed an odourless 2-methyl-5-tert-butylphenyl (Mbp) thioglycoside and trichloroacetimidate donors in one-pot reaction as a key step.

KW - HL-60 cells

KW - Mbp thioglycoside

KW - One-pot reaction

KW - Trichloroacetimidates

KW - Triterpenoid saponins

UR - https://www.scopus.com/pages/publications/67649417998

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SN - 0008-6215

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EP - 1281

JO - Carbohydrate Research

JF - Carbohydrate Research

IS - 11

ER -

Concise synthesis of two natural triterpenoid saponins, oleanolic acid derivatives isolated from the roots of Pulsatilla chinensis

Abstract

Keywords

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