Concise synthesis of two natural triterpenoid saponins, oleanolic acid derivatives isolated from the roots of Pulsatilla chinensis

Qingchao Liu, Peng Wang, Lei Zhang, Tiantian Guo, Guokai Lv, Yingxia Li

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The first synthesis of two natural triterpenoid saponins, which were isolated from the roots of Pulsatilla chinensis and exhibited excellent in vitro cytotoxic activity against HL-60 cells, was concisely achieved in a convergent approach. We employed an odourless 2-methyl-5-tert-butylphenyl (Mbp) thioglycoside and trichloroacetimidate donors in one-pot reaction as a key step.

Original languageEnglish
Pages (from-to)1276-1281
Number of pages6
JournalCarbohydrate Research
Volume344
Issue number11
DOIs
StatePublished - 27 Jul 2009
Externally publishedYes

Keywords

  • HL-60 cells
  • Mbp thioglycoside
  • One-pot reaction
  • Trichloroacetimidates
  • Triterpenoid saponins

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