Concise review: Stem cell therapy for muscular dystrophies

Karlijn J. Wilschut, Vivian B. Ling, Harold S. Bernstein

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Muscular dystrophy comprises a group of genetic diseases that cause progressive weakness and degeneration of skeletal muscle resulting from defective proteins critical to muscle structure and function. This leads to premature exhaustion of the muscle stem cell pool that maintains muscle integrity during normal use and exercise. Stem cell therapy holds promise as a treatment for muscular dystrophy by providing cells that can both deliver functional muscle proteins and replenish the stem cell pool. Here, we review the current state of research on myogenic stem cells and identify the important challenges that must be addressed as stem cell therapy is brought to the clinic.

Original languageEnglish
Pages (from-to)833-842
Number of pages10
JournalStem cells translational medicine
Issue number11
StatePublished - 2012
Externally publishedYes


  • Embryonic stem cells
  • Muscular dystrophy
  • Myogenesis
  • Stem cell
  • Tissue regeneration


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