Concise review: Current and emerging biomarkers of nephrotoxicity

Elijah J. Weber, Jonathan Himmelfarb, Edward J. Kelly

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

The kidney is a primary organ for filtration of the blood and elimination of drugs and xenobiotics. These active reabsorptive and secretory processes can result in acute kidney injury as a result of these concentrative properties. Classic measures of acute kidney injury are hampered by their ability to accurately assess function before irreversible damage has occurred. This review will discuss efforts to refine the clinical utility of standard biomarkers as well as the development of novel biomarkers of nephrotoxicity.

Original languageEnglish
Pages (from-to)16-21
Number of pages6
JournalCurrent Opinion in Toxicology
Volume4
DOIs
StatePublished - 1 Jun 2017
Externally publishedYes

Keywords

  • Acute kidney injury
  • Biomarkers
  • Nephrotoxicity

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