TY - JOUR
T1 - Conceptualizing Biological Aging and Frailty in Orthopaedics
T2 - A Framework for Clinical Practice
AU - Cong, Ting
AU - Hall, Arielle J.
AU - Jia, Zhimeng
AU - Christiano, Anthony
AU - Elsevier, Hannah C.K.
AU - Cheung, Zoe B.
AU - Wellman, David
AU - Forsh, David
AU - Lane, Joseph M.
N1 - Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.
PY - 2022/7/6
Y1 - 2022/7/6
N2 - Biological aging can best be conceptualized clinically as a combination of 3 components: frailty, comorbidity, and disability.Despite advancements in the understanding of senescence, chronological age remains the best estimate of biological age. However, a useful exercise for practitioners is to look beyond chronological age in clinical and surgical decision-making.A chronologically aging person does not age biologically at the same rate.The best way to understand frailty is to consider it as a physical phenotype.Physical optimization should parallel medical optimization before elective surgery.The poorer the host (both in terms of bone quality and propensity for healing), the more robust the implant construct must be to minimize reliance on host biology.
AB - Biological aging can best be conceptualized clinically as a combination of 3 components: frailty, comorbidity, and disability.Despite advancements in the understanding of senescence, chronological age remains the best estimate of biological age. However, a useful exercise for practitioners is to look beyond chronological age in clinical and surgical decision-making.A chronologically aging person does not age biologically at the same rate.The best way to understand frailty is to consider it as a physical phenotype.Physical optimization should parallel medical optimization before elective surgery.The poorer the host (both in terms of bone quality and propensity for healing), the more robust the implant construct must be to minimize reliance on host biology.
UR - http://www.scopus.com/inward/record.url?scp=85134243241&partnerID=8YFLogxK
U2 - 10.2106/JBJS.21.01053
DO - 10.2106/JBJS.21.01053
M3 - Review article
C2 - 35275895
AN - SCOPUS:85134243241
SN - 0021-9355
VL - 104
SP - 1212
EP - 1222
JO - Journal of Bone and Joint Surgery
JF - Journal of Bone and Joint Surgery
IS - 13
ER -