Concepts and Controversies: Lipid Management in Patients with Chronic Kidney Disease

Roy O. Mathew, Robert S. Rosenson, Radmila Lyubarova, Rafia Chaudhry, Salvatore P. Costa, Sripal Bangalore, Mandeep S. Sidhu

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Atherosclerotic cardiovascular disease (ASCVD) remains an important contributor of morbidity and mortality in patients with chronic kidney disease (CKD). CKD is recognized as an important risk enhancer that identifies patients as candidates for more intensive low-density lipoprotein (LDL) cholesterol lowering. However, there is controversy regarding the efficacy of lipid-lowering therapy, especially in patients on dialysis. Among patients with CKD, not yet on dialysis, there is clinical trial evidence for the use of statins with or without ezetimibe to reduce ASCVD events. Newer cholesterol lowering agents have been introduced for the management of hyperlipidemia to reduce ASCVD, but these therapies have not been tested in the CKD population except in secondary analyses of patients with primarily CKD stage 3. This review summarizes the role of hyperlipidemia in ASCVD and treatment strategies for hyperlipidemia in the CKD population.

Original languageEnglish
Pages (from-to)479-489
Number of pages11
JournalCardiovascular Drugs and Therapy
Volume35
Issue number3
DOIs
StatePublished - Jun 2021

Keywords

  • Atherosclerotic cardiovascular disease
  • Chronic kidney disease
  • Dyslipidemia
  • End-stage renal disease
  • PCSK9 inhibitors

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