COMT genotype and manic symptoms in schizophrenia

Pamela DeRosse; Birgit Funke; Katherine E. Burdick; Todd Lencz; Terry E. Goldberg; John M. Kane; Raju Kucherlapati; Anil K. Malhotra

doi:10.1016/j.schres.2006.06.008

COMT genotype and manic symptoms in schizophrenia

Pamela DeRosse, Birgit Funke, Katherine E. Burdick, Todd Lencz, Terry E. Goldberg, John M. Kane, Raju Kucherlapati, Anil K. Malhotra

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Inconsistencies in the relation between COMT variation and schizophrenia may be clarified by careful delineation of a target phenotype. The present study reports a significant association between a COMT haplotype and the severity of manic symptoms in 162 patients with schizophrenia or schizoaffective disorder (SZ). These data suggest that the effect of COMT variation may be associated with comorbid manic symptoms in SZ.

Original language	English
Pages (from-to)	28-31
Number of pages	4
Journal	Schizophrenia Research
Volume	87
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2006.06.008
State	Published - Oct 2006
Externally published	Yes

Keywords

COMT
Manic symptoms
Schizophrenia

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10.1016/j.schres.2006.06.008

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abstract = "Inconsistencies in the relation between COMT variation and schizophrenia may be clarified by careful delineation of a target phenotype. The present study reports a significant association between a COMT haplotype and the severity of manic symptoms in 162 patients with schizophrenia or schizoaffective disorder (SZ). These data suggest that the effect of COMT variation may be associated with comorbid manic symptoms in SZ.",

keywords = "COMT, Manic symptoms, Schizophrenia",

author = "Pamela DeRosse and Birgit Funke and Burdick, {Katherine E.} and Todd Lencz and Goldberg, {Terry E.} and Kane, {John M.} and Raju Kucherlapati and Malhotra, {Anil K.}",

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AU - DeRosse, Pamela

AU - Funke, Birgit

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AU - Lencz, Todd

AU - Goldberg, Terry E.

AU - Kane, John M.

AU - Kucherlapati, Raju

AU - Malhotra, Anil K.

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AB - Inconsistencies in the relation between COMT variation and schizophrenia may be clarified by careful delineation of a target phenotype. The present study reports a significant association between a COMT haplotype and the severity of manic symptoms in 162 patients with schizophrenia or schizoaffective disorder (SZ). These data suggest that the effect of COMT variation may be associated with comorbid manic symptoms in SZ.

KW - COMT

KW - Manic symptoms

KW - Schizophrenia

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JO - Schizophrenia Research

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ER -

COMT genotype and manic symptoms in schizophrenia

Abstract

Keywords

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