Computational Validation and Nanofabrication of Withania Somifera Extract for CNS Targeting Against Alzheimer’s Disease

Divya Jindal; Pranav Pancham; Shalini Mani; Rachana; Shazia Haider; Manisha Singh

doi:10.1007/978-981-99-3386-0_17

Computational Validation and Nanofabrication of Withania Somifera Extract for CNS Targeting Against Alzheimer’s Disease

Divya Jindal
, Pranav Pancham
, Shalini Mani
, Rachana
, Shazia Haider
, Manisha Singh

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

The prevalence and distribution of Central nervous system (CNS) disorders are increasing globally until 2021. It was estimated that 55 million people worldwide were already affected by dementia or Alzheimer's disease (AD). As a result, effective bioactive chemicals are in high demand. Withania somnifera is an Indian herb that has been used to treat a variety of neurological disorders. In our study, we have computationally evaluated the efficacy of Withania somnifera for their neuroprotective targets against AD. Thereafter, they have been formulated for the oil-in-water nano-emulsion system and optimized to attain the nanometric size range. Subsequently, Withania somnifera nanoemulsions were developed by selecting Linseed oil, Tween 20, and Ethanol as oil, surfactant, and co-surfactant respectively with an aqueous titration method. The characterization results exhibited the nanometric size range of the optimized nano-formulations.

Original language	English
Title of host publication	Recent Trends in Nanotechnology for Sustainable Living and Environment - Proceedings of ICON-NSLE 2022
Editors	Rabibrata Mukherjee, Christoph Janiak, Ziyauddin Khan, Somak Chatterjee, Banasri Roy, Sarbani Ghosh, Krishna Etika
Publisher	Springer Science and Business Media Deutschland GmbH
Pages	201-220
Number of pages	20
ISBN (Print)	9789819933853
DOIs	https://doi.org/10.1007/978-981-99-3386-0_17
State	Published - 2023
Externally published	Yes
Event	International Conference on Nanotechnology for Sustainable Living and Environment, ICON-NSLE 2022 - Jaipur, India Duration: 14 Apr 2022 → 16 Apr 2022

Publication series

Name	Lecture Notes in Mechanical Engineering
ISSN (Print)	2195-4356
ISSN (Electronic)	2195-4364

Conference

Conference	International Conference on Nanotechnology for Sustainable Living and Environment, ICON-NSLE 2022
Country/Territory	India
City	Jaipur
Period	14/04/22 → 16/04/22

Keywords

Activity-dependent neuroprotective protein
Alzheimer’s disease
Nano-emulsion
Neurodegenerative disorders
Translocator protein
Withania somnifera

Access to Document

10.1007/978-981-99-3386-0_17

Cite this

Jindal, D., Pancham, P., Mani, S., Rachana, Haider, S., & Singh, M. (2023). Computational Validation and Nanofabrication of Withania Somifera Extract for CNS Targeting Against Alzheimer’s Disease. In R. Mukherjee, C. Janiak, Z. Khan, S. Chatterjee, B. Roy, S. Ghosh, & K. Etika (Eds.), Recent Trends in Nanotechnology for Sustainable Living and Environment - Proceedings of ICON-NSLE 2022 (pp. 201-220). (Lecture Notes in Mechanical Engineering). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/978-981-99-3386-0_17

Jindal, Divya ; Pancham, Pranav ; Mani, Shalini et al. / Computational Validation and Nanofabrication of Withania Somifera Extract for CNS Targeting Against Alzheimer’s Disease. Recent Trends in Nanotechnology for Sustainable Living and Environment - Proceedings of ICON-NSLE 2022. editor / Rabibrata Mukherjee ; Christoph Janiak ; Ziyauddin Khan ; Somak Chatterjee ; Banasri Roy ; Sarbani Ghosh ; Krishna Etika. Springer Science and Business Media Deutschland GmbH, 2023. pp. 201-220 (Lecture Notes in Mechanical Engineering).

@inproceedings{a36d3e42ce4e4e0aa5a8591354a49ec0,

title = "Computational Validation and Nanofabrication of Withania Somifera Extract for CNS Targeting Against Alzheimer{\textquoteright}s Disease",

abstract = "The prevalence and distribution of Central nervous system (CNS) disorders are increasing globally until 2021. It was estimated that 55 million people worldwide were already affected by dementia or Alzheimer's disease (AD). As a result, effective bioactive chemicals are in high demand. Withania somnifera is an Indian herb that has been used to treat a variety of neurological disorders. In our study, we have computationally evaluated the efficacy of Withania somnifera for their neuroprotective targets against AD. Thereafter, they have been formulated for the oil-in-water nano-emulsion system and optimized to attain the nanometric size range. Subsequently, Withania somnifera nanoemulsions were developed by selecting Linseed oil, Tween 20, and Ethanol as oil, surfactant, and co-surfactant respectively with an aqueous titration method. The characterization results exhibited the nanometric size range of the optimized nano-formulations.",

keywords = "Activity-dependent neuroprotective protein, Alzheimer{\textquoteright}s disease, Nano-emulsion, Neurodegenerative disorders, Translocator protein, Withania somnifera",

author = "Divya Jindal and Pranav Pancham and Shalini Mani and Rachana and Shazia Haider and Manisha Singh",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.; International Conference on Nanotechnology for Sustainable Living and Environment, ICON-NSLE 2022 ; Conference date: 14-04-2022 Through 16-04-2022",

year = "2023",

doi = "10.1007/978-981-99-3386-0\_17",

language = "English",

isbn = "9789819933853",

series = "Lecture Notes in Mechanical Engineering",

publisher = "Springer Science and Business Media Deutschland GmbH",

pages = "201--220",

editor = "Rabibrata Mukherjee and Christoph Janiak and Ziyauddin Khan and Somak Chatterjee and Banasri Roy and Sarbani Ghosh and Krishna Etika",

booktitle = "Recent Trends in Nanotechnology for Sustainable Living and Environment - Proceedings of ICON-NSLE 2022",

address = "Germany",

}

Jindal, D, Pancham, P, Mani, S, Rachana, Haider, S & Singh, M 2023, Computational Validation and Nanofabrication of Withania Somifera Extract for CNS Targeting Against Alzheimer’s Disease. in R Mukherjee, C Janiak, Z Khan, S Chatterjee, B Roy, S Ghosh & K Etika (eds), Recent Trends in Nanotechnology for Sustainable Living and Environment - Proceedings of ICON-NSLE 2022. Lecture Notes in Mechanical Engineering, Springer Science and Business Media Deutschland GmbH, pp. 201-220, International Conference on Nanotechnology for Sustainable Living and Environment, ICON-NSLE 2022, Jaipur, India, 14/04/22. https://doi.org/10.1007/978-981-99-3386-0_17

Computational Validation and Nanofabrication of Withania Somifera Extract for CNS Targeting Against Alzheimer’s Disease. / Jindal, Divya; Pancham, Pranav; Mani, Shalini et al.
Recent Trends in Nanotechnology for Sustainable Living and Environment - Proceedings of ICON-NSLE 2022. ed. / Rabibrata Mukherjee; Christoph Janiak; Ziyauddin Khan; Somak Chatterjee; Banasri Roy; Sarbani Ghosh; Krishna Etika. Springer Science and Business Media Deutschland GmbH, 2023. p. 201-220 (Lecture Notes in Mechanical Engineering).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Computational Validation and Nanofabrication of Withania Somifera Extract for CNS Targeting Against Alzheimer’s Disease

AU - Jindal, Divya

AU - Pancham, Pranav

AU - Mani, Shalini

AU - Rachana,

AU - Haider, Shazia

AU - Singh, Manisha

PY - 2023

Y1 - 2023

N2 - The prevalence and distribution of Central nervous system (CNS) disorders are increasing globally until 2021. It was estimated that 55 million people worldwide were already affected by dementia or Alzheimer's disease (AD). As a result, effective bioactive chemicals are in high demand. Withania somnifera is an Indian herb that has been used to treat a variety of neurological disorders. In our study, we have computationally evaluated the efficacy of Withania somnifera for their neuroprotective targets against AD. Thereafter, they have been formulated for the oil-in-water nano-emulsion system and optimized to attain the nanometric size range. Subsequently, Withania somnifera nanoemulsions were developed by selecting Linseed oil, Tween 20, and Ethanol as oil, surfactant, and co-surfactant respectively with an aqueous titration method. The characterization results exhibited the nanometric size range of the optimized nano-formulations.

AB - The prevalence and distribution of Central nervous system (CNS) disorders are increasing globally until 2021. It was estimated that 55 million people worldwide were already affected by dementia or Alzheimer's disease (AD). As a result, effective bioactive chemicals are in high demand. Withania somnifera is an Indian herb that has been used to treat a variety of neurological disorders. In our study, we have computationally evaluated the efficacy of Withania somnifera for their neuroprotective targets against AD. Thereafter, they have been formulated for the oil-in-water nano-emulsion system and optimized to attain the nanometric size range. Subsequently, Withania somnifera nanoemulsions were developed by selecting Linseed oil, Tween 20, and Ethanol as oil, surfactant, and co-surfactant respectively with an aqueous titration method. The characterization results exhibited the nanometric size range of the optimized nano-formulations.

KW - Activity-dependent neuroprotective protein

KW - Alzheimer’s disease

KW - Nano-emulsion

KW - Neurodegenerative disorders

KW - Translocator protein

KW - Withania somnifera

UR - https://www.scopus.com/pages/publications/85164948915

U2 - 10.1007/978-981-99-3386-0_17

DO - 10.1007/978-981-99-3386-0_17

M3 - Conference contribution

AN - SCOPUS:85164948915

SN - 9789819933853

T3 - Lecture Notes in Mechanical Engineering

SP - 201

EP - 220

BT - Recent Trends in Nanotechnology for Sustainable Living and Environment - Proceedings of ICON-NSLE 2022

A2 - Mukherjee, Rabibrata

A2 - Janiak, Christoph

A2 - Khan, Ziyauddin

A2 - Chatterjee, Somak

A2 - Roy, Banasri

A2 - Ghosh, Sarbani

A2 - Etika, Krishna

PB - Springer Science and Business Media Deutschland GmbH

T2 - International Conference on Nanotechnology for Sustainable Living and Environment, ICON-NSLE 2022

Y2 - 14 April 2022 through 16 April 2022

ER -

Jindal D, Pancham P, Mani S, Rachana, Haider S, Singh M. Computational Validation and Nanofabrication of Withania Somifera Extract for CNS Targeting Against Alzheimer’s Disease. In Mukherjee R, Janiak C, Khan Z, Chatterjee S, Roy B, Ghosh S, Etika K, editors, Recent Trends in Nanotechnology for Sustainable Living and Environment - Proceedings of ICON-NSLE 2022. Springer Science and Business Media Deutschland GmbH. 2023. p. 201-220. (Lecture Notes in Mechanical Engineering). doi: 10.1007/978-981-99-3386-0_17

Computational Validation and Nanofabrication of Withania Somifera Extract for CNS Targeting Against Alzheimer’s Disease

Abstract

Publication series

Conference

Keywords

Access to Document

Fingerprint

Cite this