Computational Anatomy in Alzheimer's Disease

Alex D. Leow, Liana G. Apostolova, Paul M. Thompson

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Computational anatomy covers a broad class of mathematical methods that model anatomical structures in images as three-dimensional curves, surfaces and volumes, and combine them across subjects to create statistical maps of structural differences among brains. The methods described here are cortical thickness mapping, time-lapse, tensor-based morphometry, and hippocampal radial mapping.

Original languageEnglish
Title of host publicationPrinciples and Practice of Geriatric Psychiatry
Subtitle of host publicationThird Edition
PublisherJohn Wiley and Sons
Number of pages9
ISBN (Print)9780470747230
StatePublished - 2 Dec 2010
Externally publishedYes


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