TY - JOUR
T1 - Compulsivity in obsessive-compulsive disorder and addictions
AU - Figee, Martijn
AU - Pattij, Tommy
AU - Willuhn, Ingo
AU - Luigjes, Judy
AU - van den Brink, Wim
AU - Goudriaan, Anneke
AU - Potenza, Marc N.
AU - Robbins, Trevor W.
AU - Denys, Damiaan
N1 - Funding Information:
This work was supported in part by the NIH ( P20 DA027844 ), the Connecticut State Department of Mental Health and Addictions Services, and the Yale Gambling Center of Research Excellence grant from the National Center for Responsible Gaming. The NIH, the Connecticut State Department of Mental Health and Addictions Services, and the National Center for Responsible Gaming had no role in the content or writing of the manuscript or the decision to submit the paper for publication.
Funding Information:
Dr. Potenza has received financial support or compensation for the following: has acted as consultant and/or advisor for Somaxon, Boehringer Ingelheim, Lundbeck, Ironwood, Shire, INSYS, and RiverMend Health; has received research support from the National Institutes of Health, Veterans Administration, Mohegan Sun Casino, the National Center for Responsible Gaming, Forest Laboratories, Ortho-McNeil, Oy-Contral Pharma/Biotie Therapies, GlaxoSmithKline, and Psyadon Pharmaceuticals; has participated in surveys, mailings or telephone consultations related to drug addiction, impulse control disorders, and other health topics; has consulted for law offices and the federal public defender׳s office on issues related to impulse control disorders; provides clinical care in the Connecticut Department of Mental Health and Addiction Services Problem Gambling Services Program; has performed grant reviews for the National Institutes of Health and other agencies; has acted as guest editor for journal sections and journals; has given academic lectures in grand rounds, CME events, and other clinical and scientific venues; and has generated books or book chapters for publishers of mental health texts.
Publisher Copyright:
© 2016.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Compulsive behaviors are driven by repetitive urges and typically involve the experience of limited voluntary control over these urges, a diminished ability to delay or inhibit these behaviors, and a tendency to perform repetitive acts in a habitual or stereotyped manner. Compulsivity is not only a central characteristic of obsessive-compulsive disorder (OCD) but is also crucial to addiction. Based on this analogy, OCD has been proposed to be part of the concept of behavioral addiction along with other non-drug-related disorders that share compulsivity, such as pathological gambling, skin-picking, trichotillomania and compulsive eating. In this review, we investigate the neurobiological overlap between compulsivity in substance-use disorders, OCD and behavioral addictions as a validation for the construct of compulsivity that could be adopted in the Research Domain Criteria (RDoC). The reviewed data suggest that compulsivity in OCD and addictions is related to impaired reward and punishment processing with attenuated dopamine release in the ventral striatum, negative reinforcement in limbic systems, cognitive and behavioral inflexibility with diminished serotonergic prefrontal control, and habitual responding with imbalances between ventral and dorsal frontostriatal recruitment. Frontostriatal abnormalities of compulsivity are promising targets for neuromodulation and other interventions for OCD and addictions. We conclude that compulsivity encompasses many of the RDoC constructs in a trans-diagnostic fashion with a common brain circuit dysfunction that can help identifying appropriate prevention and treatment targets.
AB - Compulsive behaviors are driven by repetitive urges and typically involve the experience of limited voluntary control over these urges, a diminished ability to delay or inhibit these behaviors, and a tendency to perform repetitive acts in a habitual or stereotyped manner. Compulsivity is not only a central characteristic of obsessive-compulsive disorder (OCD) but is also crucial to addiction. Based on this analogy, OCD has been proposed to be part of the concept of behavioral addiction along with other non-drug-related disorders that share compulsivity, such as pathological gambling, skin-picking, trichotillomania and compulsive eating. In this review, we investigate the neurobiological overlap between compulsivity in substance-use disorders, OCD and behavioral addictions as a validation for the construct of compulsivity that could be adopted in the Research Domain Criteria (RDoC). The reviewed data suggest that compulsivity in OCD and addictions is related to impaired reward and punishment processing with attenuated dopamine release in the ventral striatum, negative reinforcement in limbic systems, cognitive and behavioral inflexibility with diminished serotonergic prefrontal control, and habitual responding with imbalances between ventral and dorsal frontostriatal recruitment. Frontostriatal abnormalities of compulsivity are promising targets for neuromodulation and other interventions for OCD and addictions. We conclude that compulsivity encompasses many of the RDoC constructs in a trans-diagnostic fashion with a common brain circuit dysfunction that can help identifying appropriate prevention and treatment targets.
KW - Addiction
KW - Behavioral addiction
KW - Frontostriatal network
KW - Obsessive-compulsive disorder
KW - RDoC
KW - Substance-use
UR - http://www.scopus.com/inward/record.url?scp=84969651342&partnerID=8YFLogxK
U2 - 10.1016/j.euroneuro.2015.12.003
DO - 10.1016/j.euroneuro.2015.12.003
M3 - Article
C2 - 26774279
AN - SCOPUS:84969651342
SN - 0924-977X
VL - 26
SP - 856
EP - 868
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
IS - 5
ER -