Comprehensive characterization of cellular immune responses following ebola virus infection

Christine Dahlke; Sebastian Lunemann; Rahel Kasonta; Benno Kreuels; Stefan Schmiedel; My L. Ly; Sarah K. Fehling; Thomas Strecker; Stephan Becker; Marcus Altfeld; Abdourahmane Sow; Ansgar W. Lohse; César Muñoz-Fontela; Marylyn M. Addo

doi:10.1093/infdis/jiw508

Comprehensive characterization of cellular immune responses following ebola virus infection

Christine Dahlke
, Sebastian Lunemann
, Rahel Kasonta
, Benno Kreuels
, Stefan Schmiedel
, My L. Ly
, Sarah K. Fehling
, Thomas Strecker
, Stephan Becker
, Marcus Altfeld
, Abdourahmane Sow
, Ansgar W. Lohse
, César Muñoz-Fontela
, Marylyn M. Addo

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

The West African Ebola virus disease (EVD) outbreak was the largest EVD outbreak in history. However, data on lymphocyte dynamics and the antigen specificity of T cells in Ebola survivors are scarce, and our understanding of EVD pathophysiology is limited. A case of EVD survival in which the patient cleared Ebola virus (EBOV) infection without experimental drugs allowed for the detailed examination of lymphocyte dynamics. We demonstrate the persistence of T-cell activation well beyond viral clearance and detect EBOV-specific T cells. Our study provides significant insights into lymphocyte specificity during the recovery phase of EVD and may inform novel strategies to treat EVD.

Original language	English
Pages (from-to)	287-292
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	215
Issue number	2
DOIs	https://doi.org/10.1093/infdis/jiw508
State	Published - 15 Jan 2017
Externally published	Yes

Keywords

Cellular immune response
Convalescent phase
EVD
EVD survivor
Ebola GP-specific T-cell responses
Lymphocyte dynamics
Polyfunctional T-cell responses
T-cell activation

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10.1093/infdis/jiw508

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Dahlke, C., Lunemann, S., Kasonta, R., Kreuels, B., Schmiedel, S., Ly, M. L., Fehling, S. K., Strecker, T., Becker, S., Altfeld, M., Sow, A., Lohse, A. W., Muñoz-Fontela, C., & Addo, M. M. (2017). Comprehensive characterization of cellular immune responses following ebola virus infection. Journal of Infectious Diseases, 215(2), 287-292. https://doi.org/10.1093/infdis/jiw508

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title = "Comprehensive characterization of cellular immune responses following ebola virus infection",

abstract = "The West African Ebola virus disease (EVD) outbreak was the largest EVD outbreak in history. However, data on lymphocyte dynamics and the antigen specificity of T cells in Ebola survivors are scarce, and our understanding of EVD pathophysiology is limited. A case of EVD survival in which the patient cleared Ebola virus (EBOV) infection without experimental drugs allowed for the detailed examination of lymphocyte dynamics. We demonstrate the persistence of T-cell activation well beyond viral clearance and detect EBOV-specific T cells. Our study provides significant insights into lymphocyte specificity during the recovery phase of EVD and may inform novel strategies to treat EVD.",

keywords = "Cellular immune response, Convalescent phase, EVD, EVD survivor, Ebola GP-specific T-cell responses, Lymphocyte dynamics, Polyfunctional T-cell responses, T-cell activation",

author = "Christine Dahlke and Sebastian Lunemann and Rahel Kasonta and Benno Kreuels and Stefan Schmiedel and Ly, \{My L.\} and Fehling, \{Sarah K.\} and Thomas Strecker and Stephan Becker and Marcus Altfeld and Abdourahmane Sow and Lohse, \{Ansgar W.\} and C{\'e}sar Mu{\~n}oz-Fontela and Addo, \{Marylyn M.\}",

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doi = "10.1093/infdis/jiw508",

language = "English",

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AU - Dahlke, Christine

AU - Lunemann, Sebastian

AU - Kasonta, Rahel

AU - Kreuels, Benno

AU - Schmiedel, Stefan

AU - Ly, My L.

AU - Fehling, Sarah K.

AU - Strecker, Thomas

AU - Becker, Stephan

AU - Altfeld, Marcus

AU - Sow, Abdourahmane

AU - Lohse, Ansgar W.

AU - Muñoz-Fontela, César

AU - Addo, Marylyn M.

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N2 - The West African Ebola virus disease (EVD) outbreak was the largest EVD outbreak in history. However, data on lymphocyte dynamics and the antigen specificity of T cells in Ebola survivors are scarce, and our understanding of EVD pathophysiology is limited. A case of EVD survival in which the patient cleared Ebola virus (EBOV) infection without experimental drugs allowed for the detailed examination of lymphocyte dynamics. We demonstrate the persistence of T-cell activation well beyond viral clearance and detect EBOV-specific T cells. Our study provides significant insights into lymphocyte specificity during the recovery phase of EVD and may inform novel strategies to treat EVD.

AB - The West African Ebola virus disease (EVD) outbreak was the largest EVD outbreak in history. However, data on lymphocyte dynamics and the antigen specificity of T cells in Ebola survivors are scarce, and our understanding of EVD pathophysiology is limited. A case of EVD survival in which the patient cleared Ebola virus (EBOV) infection without experimental drugs allowed for the detailed examination of lymphocyte dynamics. We demonstrate the persistence of T-cell activation well beyond viral clearance and detect EBOV-specific T cells. Our study provides significant insights into lymphocyte specificity during the recovery phase of EVD and may inform novel strategies to treat EVD.

KW - Cellular immune response

KW - Convalescent phase

KW - EVD

KW - EVD survivor

KW - Ebola GP-specific T-cell responses

KW - Lymphocyte dynamics

KW - Polyfunctional T-cell responses

KW - T-cell activation

UR - https://www.scopus.com/pages/publications/85019525810

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DO - 10.1093/infdis/jiw508

M3 - Article

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AN - SCOPUS:85019525810

SN - 0022-1899

VL - 215

SP - 287

EP - 292

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 2

ER -

Comprehensive characterization of cellular immune responses following ebola virus infection

Abstract

Keywords

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