Complicated Migraine

Mark W. Green, Rachel Colman

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The term "complicated migraine" (CM) is often applied to unexplained transient neurological symptoms by clinicians. CM is a diagnosis requiring an exclusion of other pathologies using rigorous criteria. The varied symptoms and presentations of complex aura are a fascinating window into the pathophysiology of migraine. Unilateral, bilateral, positive, and negative phenomena all occur, and are transient, reversible, and generally without permanent neurological sequelae. CM requires prompt medical attention to rule out other neurological disorders that may be amenable to treatment. In a presentation in which cerebral infarction is a likely differential diagnosis, triptans are avoided. Connecting its multiple presentations is a common denominator: the difficulty in diagnosis and lack of data to support preventive and acute therapies. This can be frustrating for the patient and clinician. There is need for further research and discovery in this field.

Original languageEnglish
Title of host publicationHeadache and Migraine Biology and Management
PublisherElsevier Inc.
Number of pages10
ISBN (Electronic)9780128011621
ISBN (Print)9780128009017
StatePublished - 13 Mar 2015


  • Basilar migraine
  • Familial hemiplegic migraine
  • Migraine with brainstem aura
  • Ophthalmoplegic migraine
  • Prolonged aura
  • Retinal migraine
  • Sporadic hemiplegic migraine


Dive into the research topics of 'Complicated Migraine'. Together they form a unique fingerprint.

Cite this