Complexity in signal transduction

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

10 Scopus citations


This review is focused on complexity in cell signaling. Signaling experiments have demonstrated that many different stimuli activate the same signaling pathways yet result in different outcomes. Differences in the cellular machinery between cells explain response variation between cell types, but for a single cell type an appealing explanation is still lacking. The kinetic disconnect between cell signal transduction and a cellular action is highlighted; possible explanations for this disconnect, such as a series of cascading autocrine signaling molecules and new research suggesting that cells experience multiple rounds of reactivation in numerous cell signaling pathways, are reviewed. Additionally, evidence that kinase pathways exhibit frequency and amplitude modulation is examined. From this review, a new model of signal transduction is proposed whereby multiple signal transduction pathways are reactivated over time to orchestrate unique outcomes in physiological processes.

Original languageEnglish
Title of host publicationSkeletal Biology and Medicine
PublisherBlackwell Publishing Inc.
Number of pages7
ISBN (Print)9781573317856
StatePublished - Mar 2010

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632


  • ERK
  • Gene transcription
  • JNK
  • NF-κB
  • Oscillations
  • P38
  • Signal transduction
  • TNF


Dive into the research topics of 'Complexity in signal transduction'. Together they form a unique fingerprint.

Cite this