Complex I and MDM2: hit me baby one more time

Jerry Edward Chipuk

doi:10.1080/23723556.2019.1607457

Complex I and MDM2: hit me baby one more time

Jerry Edward Chipuk

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

MDM2 (mouse double minute 2) functions as both a tumor suppressor and oncogene, yet little is known if MDM2 regulates cancer cell biology by altering cellular metabolism. We recently found that MDM2 binds NDUFS1 (NADH:ubiquinone oxidoreductase 75 kDa Fe-S protein 1), a key protein involved in Complex I assembly, function, and efficiency. The MDM2⋅NDUFS1 interaction promotes reactive oxygen species production, DNA damage, and apoptosis.

Original language	English
Article number	1607457
Journal	Molecular and Cellular Oncology
Volume	6
Issue number	4
DOIs	https://doi.org/10.1080/23723556.2019.1607457
State	Published - 4 Jul 2019

Keywords

Apoptosis
Complex I
MDM2
NDUFS1
mitochondria

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title = "Complex I and MDM2: hit me baby one more time",

abstract = "MDM2 (mouse double minute 2) functions as both a tumor suppressor and oncogene, yet little is known if MDM2 regulates cancer cell biology by altering cellular metabolism. We recently found that MDM2 binds NDUFS1 (NADH:ubiquinone oxidoreductase 75 kDa Fe-S protein 1), a key protein involved in Complex I assembly, function, and efficiency. The MDM2⋅NDUFS1 interaction promotes reactive oxygen species production, DNA damage, and apoptosis.",

keywords = "Apoptosis, Complex I, MDM2, NDUFS1, mitochondria",

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KW - Apoptosis

KW - Complex I

KW - MDM2

KW - NDUFS1

KW - mitochondria

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Complex I and MDM2: hit me baby one more time

Abstract

Keywords

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