MDM2 (mouse double minute 2) functions as both a tumor suppressor and oncogene, yet little is known if MDM2 regulates cancer cell biology by altering cellular metabolism. We recently found that MDM2 binds NDUFS1 (NADH:ubiquinone oxidoreductase 75 kDa Fe-S protein 1), a key protein involved in Complex I assembly, function, and efficiency. The MDM2⋅NDUFS1 interaction promotes reactive oxygen species production, DNA damage, and apoptosis.

Original languageEnglish
Article number1607457
JournalMolecular and Cellular Oncology
Issue number4
StatePublished - 4 Jul 2019


  • Apoptosis
  • Complex I
  • MDM2
  • NDUFS1
  • mitochondria


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