@article{e86294bad1654241ac50b4ced479036d,
title = "Complex I and MDM2: hit me baby one more time",
abstract = "MDM2 (mouse double minute 2) functions as both a tumor suppressor and oncogene, yet little is known if MDM2 regulates cancer cell biology by altering cellular metabolism. We recently found that MDM2 binds NDUFS1 (NADH:ubiquinone oxidoreductase 75 kDa Fe-S protein 1), a key protein involved in Complex I assembly, function, and efficiency. The MDM2⋅NDUFS1 interaction promotes reactive oxygen species production, DNA damage, and apoptosis.",
keywords = "Apoptosis, Complex I, MDM2, NDUFS1, mitochondria",
author = "Chipuk, {Jerry Edward}",
note = "Funding Information: This work was supported by: NIH grants R01 CA157740 and R01 CA206005; the JJR Foundation, the William A. Spivak Fund, the Fridolin Charitable Trust, an American Cancer Society Research Scholar Award, a Leukemia & Lymphoma Society Career Development Award, and an Irma T. Hirschl/Monique Weill Caulier Trust Research Award. This work was also supported in part by two research grants (5FY1174 and 1FY13416) from the March of Dimes Foundation, the Developmental Research Pilot Project Program within the Department of Oncological Sciences at the Icahn School of Medicine at Mount Sinai, a Collaborative Pilot Award from the Melanoma Research Alliance, and the Tisch Cancer Institute Cancer Center Support Grant (P30 CA196521). Publisher Copyright: {\textcopyright} 2019, {\textcopyright} 2019 Taylor & Francis Group, LLC.",
year = "2019",
month = jul,
day = "4",
doi = "10.1080/23723556.2019.1607457",
language = "English",
volume = "6",
journal = "Molecular and Cellular Oncology",
issn = "2372-3556",
publisher = "Taylor and Francis Ltd.",
number = "4",
}