Abstract
MDM2 (mouse double minute 2) functions as both a tumor suppressor and oncogene, yet little is known if MDM2 regulates cancer cell biology by altering cellular metabolism. We recently found that MDM2 binds NDUFS1 (NADH:ubiquinone oxidoreductase 75 kDa Fe-S protein 1), a key protein involved in Complex I assembly, function, and efficiency. The MDM2⋅NDUFS1 interaction promotes reactive oxygen species production, DNA damage, and apoptosis.
Original language | English |
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Article number | 1607457 |
Journal | Molecular and Cellular Oncology |
Volume | 6 |
Issue number | 4 |
DOIs | |
State | Published - 4 Jul 2019 |
Keywords
- Apoptosis
- Complex I
- MDM2
- NDUFS1
- mitochondria