Complete sequencing of plasmids containing blaOXA-163 and blaOXA-48 in Escherichia coli sequence type 131

Nicole Stoesser; Anna E. Sheppard; Gisele Peirano; Robert Sebra; Tarah Lynch; Luke Anson; Andrew Kasarskis; Mary R. Motyl; Derrick W. Crook; Johann D. Pitout

doi:10.1128/AAC.01130-16

Complete sequencing of plasmids containing bla_OXA-163 and bla_OXA-48 in Escherichia coli sequence type 131

Nicole Stoesser
, Anna E. Sheppard
, Gisele Peirano
, Robert Sebra
, Tarah Lynch
, Luke Anson
, Andrew Kasarskis
, Mary R. Motyl
, Derrick W. Crook
, Johann D. Pitout

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

OXA-48-like enzymes have emerged as important extended-spectrum β-lactamases/carbapenemases in Escherichia coli sequence type 131 (ST131). We report the structures of the first fully sequenced bla_OXA-163 plasmid and of two other bla_OXA-48 plasmids in this lineage. bla_OXA-163 was located on a 71-kb IncN plasmid with other resistance genes. bla_OXA-48 was present on IncL/M plasmids, genetically similar to other bla_OXA-48 plasmid sequences, and consistent with interspecies/interlineage spread. The presence of bla_OXA-48-like genes on epidemic plasmids in ST131 is of concern.

Original language	English
Pages (from-to)	6948-6951
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	60
Issue number	11
DOIs	https://doi.org/10.1128/AAC.01130-16
State	Published - 1 Nov 2016

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title = "Complete sequencing of plasmids containing blaOXA-163 and blaOXA-48 in Escherichia coli sequence type 131",

abstract = "OXA-48-like enzymes have emerged as important extended-spectrum β-lactamases/carbapenemases in Escherichia coli sequence type 131 (ST131). We report the structures of the first fully sequenced blaOXA-163 plasmid and of two other blaOXA-48 plasmids in this lineage. blaOXA-163 was located on a 71-kb IncN plasmid with other resistance genes. blaOXA-48 was present on IncL/M plasmids, genetically similar to other blaOXA-48 plasmid sequences, and consistent with interspecies/interlineage spread. The presence of blaOXA-48-like genes on epidemic plasmids in ST131 is of concern.",

author = "Nicole Stoesser and Sheppard, \{Anna E.\} and Gisele Peirano and Robert Sebra and Tarah Lynch and Luke Anson and Andrew Kasarskis and Motyl, \{Mary R.\} and Crook, \{Derrick W.\} and Pitout, \{Johann D.\}",

year = "2016",

month = nov,

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doi = "10.1128/AAC.01130-16",

language = "English",

volume = "60",

pages = "6948--6951",

journal = "Antimicrobial Agents and Chemotherapy",

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publisher = "American Society for Microbiology",

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TY - JOUR

T1 - Complete sequencing of plasmids containing blaOXA-163 and blaOXA-48 in Escherichia coli sequence type 131

AU - Stoesser, Nicole

AU - Sheppard, Anna E.

AU - Peirano, Gisele

AU - Sebra, Robert

AU - Lynch, Tarah

AU - Anson, Luke

AU - Kasarskis, Andrew

AU - Motyl, Mary R.

AU - Crook, Derrick W.

AU - Pitout, Johann D.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - OXA-48-like enzymes have emerged as important extended-spectrum β-lactamases/carbapenemases in Escherichia coli sequence type 131 (ST131). We report the structures of the first fully sequenced blaOXA-163 plasmid and of two other blaOXA-48 plasmids in this lineage. blaOXA-163 was located on a 71-kb IncN plasmid with other resistance genes. blaOXA-48 was present on IncL/M plasmids, genetically similar to other blaOXA-48 plasmid sequences, and consistent with interspecies/interlineage spread. The presence of blaOXA-48-like genes on epidemic plasmids in ST131 is of concern.

AB - OXA-48-like enzymes have emerged as important extended-spectrum β-lactamases/carbapenemases in Escherichia coli sequence type 131 (ST131). We report the structures of the first fully sequenced blaOXA-163 plasmid and of two other blaOXA-48 plasmids in this lineage. blaOXA-163 was located on a 71-kb IncN plasmid with other resistance genes. blaOXA-48 was present on IncL/M plasmids, genetically similar to other blaOXA-48 plasmid sequences, and consistent with interspecies/interlineage spread. The presence of blaOXA-48-like genes on epidemic plasmids in ST131 is of concern.

UR - https://www.scopus.com/pages/publications/84994481893

U2 - 10.1128/AAC.01130-16

DO - 10.1128/AAC.01130-16

M3 - Article

C2 - 27600043

AN - SCOPUS:84994481893

SN - 0066-4804

VL - 60

SP - 6948

EP - 6951

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 11

ER -

Complete sequencing of plasmids containing blaOXA-163 and blaOXA-48 in Escherichia coli sequence type 131

Abstract

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Complete sequencing of plasmids containing bla_OXA-163 and bla_OXA-48 in Escherichia coli sequence type 131