Complete sequencing of plasmids containing blaOXA-163 and blaOXA-48 in Escherichia coli sequence type 131

Nicole Stoesser; Anna E. Sheppard; Gisele Peirano; Robert Sebra; Tarah Lynch; Luke Anson; Andrew Kasarskis; Mary R. Motyl; Derrick W. Crook; Johann D. Pitout

doi:10.1128/AAC.01130-16

Complete sequencing of plasmids containing bla_OXA-163 and bla_OXA-48 in Escherichia coli sequence type 131

Nicole Stoesser, Anna E. Sheppard, Gisele Peirano, Robert Sebra, Tarah Lynch, Luke Anson, Andrew Kasarskis, Mary R. Motyl, Derrick W. Crook, Johann D. Pitout

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

OXA-48-like enzymes have emerged as important extended-spectrum β-lactamases/carbapenemases in Escherichia coli sequence type 131 (ST131). We report the structures of the first fully sequenced bla_OXA-163 plasmid and of two other bla_OXA-48 plasmids in this lineage. bla_OXA-163 was located on a 71-kb IncN plasmid with other resistance genes. bla_OXA-48 was present on IncL/M plasmids, genetically similar to other bla_OXA-48 plasmid sequences, and consistent with interspecies/interlineage spread. The presence of bla_OXA-48-like genes on epidemic plasmids in ST131 is of concern.

Original language	English
Pages (from-to)	6948-6951
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	60
Issue number	11
DOIs	https://doi.org/10.1128/AAC.01130-16
State	Published - 1 Nov 2016

Access to Document

10.1128/AAC.01130-16

Cite this

@article{090c0f8792234e648d54015d38e42064,

title = "Complete sequencing of plasmids containing blaOXA-163 and blaOXA-48 in Escherichia coli sequence type 131",

abstract = "OXA-48-like enzymes have emerged as important extended-spectrum β-lactamases/carbapenemases in Escherichia coli sequence type 131 (ST131). We report the structures of the first fully sequenced blaOXA-163 plasmid and of two other blaOXA-48 plasmids in this lineage. blaOXA-163 was located on a 71-kb IncN plasmid with other resistance genes. blaOXA-48 was present on IncL/M plasmids, genetically similar to other blaOXA-48 plasmid sequences, and consistent with interspecies/interlineage spread. The presence of blaOXA-48-like genes on epidemic plasmids in ST131 is of concern.",

author = "Nicole Stoesser and Sheppard, \{Anna E.\} and Gisele Peirano and Robert Sebra and Tarah Lynch and Luke Anson and Andrew Kasarskis and Motyl, \{Mary R.\} and Crook, \{Derrick W.\} and Pitout, \{Johann D.\}",

year = "2016",

month = nov,

day = "1",

doi = "10.1128/AAC.01130-16",

language = "English",

volume = "60",

pages = "6948--6951",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "11",

}

TY - JOUR

T1 - Complete sequencing of plasmids containing blaOXA-163 and blaOXA-48 in Escherichia coli sequence type 131

AU - Stoesser, Nicole

AU - Sheppard, Anna E.

AU - Peirano, Gisele

AU - Sebra, Robert

AU - Lynch, Tarah

AU - Anson, Luke

AU - Kasarskis, Andrew

AU - Motyl, Mary R.

AU - Crook, Derrick W.

AU - Pitout, Johann D.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - OXA-48-like enzymes have emerged as important extended-spectrum β-lactamases/carbapenemases in Escherichia coli sequence type 131 (ST131). We report the structures of the first fully sequenced blaOXA-163 plasmid and of two other blaOXA-48 plasmids in this lineage. blaOXA-163 was located on a 71-kb IncN plasmid with other resistance genes. blaOXA-48 was present on IncL/M plasmids, genetically similar to other blaOXA-48 plasmid sequences, and consistent with interspecies/interlineage spread. The presence of blaOXA-48-like genes on epidemic plasmids in ST131 is of concern.

AB - OXA-48-like enzymes have emerged as important extended-spectrum β-lactamases/carbapenemases in Escherichia coli sequence type 131 (ST131). We report the structures of the first fully sequenced blaOXA-163 plasmid and of two other blaOXA-48 plasmids in this lineage. blaOXA-163 was located on a 71-kb IncN plasmid with other resistance genes. blaOXA-48 was present on IncL/M plasmids, genetically similar to other blaOXA-48 plasmid sequences, and consistent with interspecies/interlineage spread. The presence of blaOXA-48-like genes on epidemic plasmids in ST131 is of concern.

UR - https://www.scopus.com/pages/publications/84994481893

U2 - 10.1128/AAC.01130-16

DO - 10.1128/AAC.01130-16

M3 - Article

C2 - 27600043

AN - SCOPUS:84994481893

SN - 0066-4804

VL - 60

SP - 6948

EP - 6951

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 11

ER -

Complete sequencing of plasmids containing blaOXA-163 and blaOXA-48 in Escherichia coli sequence type 131

Abstract

Access to Document

Fingerprint

Cite this

Complete sequencing of plasmids containing bla_OXA-163 and bla_OXA-48 in Escherichia coli sequence type 131