Competing Genetic Traits and Their Influence on LDL Cholesterol Concentration in Familial Hypercholesterolemia

Christopher Song; Robert S. Rosenson

doi:10.1016/j.jaccas.2023.102171

Competing Genetic Traits and Their Influence on LDL Cholesterol Concentration in Familial Hypercholesterolemia

Christopher Song
, Robert S. Rosenson

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Familial hypercholesterolemia is a monogenic disorder that leads to premature atherosclerosis as a result of lifelong exposure to elevated low-density lipoprotein cholesterol (LDL-C). Both genetic traits and lifestyle factors can influence LDL-C levels. Adults with LDL-C of 170 mg/dL and higher may benefit from genetic evaluation to accurately assess their risk of atherosclerosis.

Original language	English
Article number	102171
Journal	JACC: Case Reports
Volume	29
Issue number	2
DOIs	https://doi.org/10.1016/j.jaccas.2023.102171
State	Published - 17 Jan 2024

Keywords

PCSK9 deficiency
familial hypercholesterolemia

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10.1016/j.jaccas.2023.102171

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title = "Competing Genetic Traits and Their Influence on LDL Cholesterol Concentration in Familial Hypercholesterolemia",

abstract = "Familial hypercholesterolemia is a monogenic disorder that leads to premature atherosclerosis as a result of lifelong exposure to elevated low-density lipoprotein cholesterol (LDL-C). Both genetic traits and lifestyle factors can influence LDL-C levels. Adults with LDL-C of 170 mg/dL and higher may benefit from genetic evaluation to accurately assess their risk of atherosclerosis.",

keywords = "PCSK9 deficiency, familial hypercholesterolemia",

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AU - Song, Christopher

AU - Rosenson, Robert S.

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N2 - Familial hypercholesterolemia is a monogenic disorder that leads to premature atherosclerosis as a result of lifelong exposure to elevated low-density lipoprotein cholesterol (LDL-C). Both genetic traits and lifestyle factors can influence LDL-C levels. Adults with LDL-C of 170 mg/dL and higher may benefit from genetic evaluation to accurately assess their risk of atherosclerosis.

AB - Familial hypercholesterolemia is a monogenic disorder that leads to premature atherosclerosis as a result of lifelong exposure to elevated low-density lipoprotein cholesterol (LDL-C). Both genetic traits and lifestyle factors can influence LDL-C levels. Adults with LDL-C of 170 mg/dL and higher may benefit from genetic evaluation to accurately assess their risk of atherosclerosis.

KW - PCSK9 deficiency

KW - familial hypercholesterolemia

UR - https://www.scopus.com/pages/publications/85179782170

U2 - 10.1016/j.jaccas.2023.102171

DO - 10.1016/j.jaccas.2023.102171

M3 - Article

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SN - 2666-0849

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JO - JACC: Case Reports

JF - JACC: Case Reports

IS - 2

M1 - 102171

ER -

Competing Genetic Traits and Their Influence on LDL Cholesterol Concentration in Familial Hypercholesterolemia

Abstract

Keywords

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