Competing Genetic Traits and Their Influence on LDL Cholesterol Concentration in Familial Hypercholesterolemia

Christopher Song, Robert S. Rosenson

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Familial hypercholesterolemia is a monogenic disorder that leads to premature atherosclerosis as a result of lifelong exposure to elevated low-density lipoprotein cholesterol (LDL-C). Both genetic traits and lifestyle factors can influence LDL-C levels. Adults with LDL-C of 170 mg/dL and higher may benefit from genetic evaluation to accurately assess their risk of atherosclerosis.

Original languageEnglish
Article number102171
JournalJACC: Case Reports
Volume29
Issue number2
DOIs
StatePublished - 17 Jan 2024

Keywords

  • PCSK9 deficiency
  • familial hypercholesterolemia

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