TY - JOUR
T1 - Comparisons of high-risk cervical HPV infections in Caribbean and US populations
AU - Ragin, Camille C.
AU - Watt, Angela
AU - Markovic, Nina
AU - Bunker, Clareann H.
AU - Edwards, Robert P.
AU - Eckstein, Stacy
AU - Fletcher, Horace
AU - Garwood, David
AU - Gollin, Susanne M.
AU - Jackson, Maria
AU - Patrick, Alan L.
AU - Smikle, M.
AU - Taioli, Emanuela
AU - Wheeler, Victor W.
AU - Wilson, Jacque B.
AU - Younger, N.
AU - McFarlane-Anderson, Norma
N1 - Funding Information:
This work is supported in part by NIH/R13 CA130596A, the UPCI Cancer Education and Career Development grant R25CA089507, and a GLMA foundation grant. This publication was also made possible by Grant Number KL2 RR024154-03 to CCR, from the National Center for Research Resources (NCRR) [23], a component of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research [24]. Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NCRR or NIH. This publication was also supported by funds received from the NIH/NCRR GCRC Grant MO1-RR000056 and/or the CTSA Grant 1 UL 1 RR024153-01. The authors wish to thank the Tobago Branch of the Trinidad & Tobago Cancer Society for providing the facilities for subject recruitment and sample collection for the Tobago subjects.
Funding Information:
<supplement> <title> <p>Second Annual International African-Caribbean Cancer Consortium Conference</p> </title> <editor>Camille Ragin and Emanuela Taioli</editor> <sponsor> <note>Publication supported in part by the University Of Pittsburgh Graduate School Of Public Health, the University of Pittsburgh Cancer Institute, and by the National Institute of Health, grant number R13CA130596A.</note> </sponsor> <note>Proceedings</note> <url>http://www.biomedcentral.com/content/pdf/1750-9378-4-S1-info.pdf</url> </supplement>
PY - 2009
Y1 - 2009
N2 - Background. Disparities in cervical cancer incidence and mortality rates exist among women of African ancestry (African-American, African-Caribbean and African). Persistent cervical infection with Human papillomavirus (HPV) is associated with cervical dysplasia and if untreated, could potentially progress to invasive cervical cancer. Very few studies have been conducted to examine the true prevalence of HPV infection in this population. Comparisons of cervical HPV infection and the type-specific distribution of HPV were performed between cancer-free Caribbean and US women. Results. The Caribbean population consisted of 212 women from Tobago and 99 women from Jamaica. The US population tested, consisted of 82 women from Pittsburgh. The majority of the US subjects was Caucasian, 74% (61/82) while 12% (10/82) and 13% (11/82) were African-American or other ethnic groups, respectively. The age-adjusted prevalence of any HPV infection among women from Tobago was 35%, while for Jamaica, it was 81% (p < 0.0001). The age-adjusted prevalence of HPV infection for Caribbean subjects was not statistically significantly different from the US (any HPV: 47% vs. 39%, p > 0.1; high-risk HPVs: 27% vs. 25%, p > 0.1); no difference was observed between US-Blacks and Jamaicans (any HPV: 92% vs. 81%, p > 0.1; high-risk HPV: 50% vs. 53%, p > 0.1). However, US-Whites had a lower age-adjusted prevalence of HPV infections compared to Jamaican subjects (any HPV: 29% vs. 81%, p < 0.0001; high-risk HPV: 20% vs. 53%, p < 0.001). Subjects from Jamaica, Tobago, and US-Blacks had a higher proportion of high-risk HPV infections (Tobago: 20%, Jamaica: 58%, US-Blacks: 40%) compared to US-Whites (15%). Similar observations were made for the presence of infections with multiple high-risk HPV types (Tobago: 12%, Jamaica: 43%, US-Blacks: 30%, US-Whites: 8%). Although we observed similar prevalence of HPV16 infections among Caribbean and US-White women, there was a distinct distribution of high-risk HPV types when comparisons were made between the ethnic groups. Conclusion. The higher prevalence of cervical HPV infections and multiple high-risk infections in Caribbean and US-Black women may contribute to the high incidence and prevalence of cervical cancer in these populations. Evaluation of a larger sample size is currently ongoing to confirm the distinct distribution of HPV types between ethnic groups.
AB - Background. Disparities in cervical cancer incidence and mortality rates exist among women of African ancestry (African-American, African-Caribbean and African). Persistent cervical infection with Human papillomavirus (HPV) is associated with cervical dysplasia and if untreated, could potentially progress to invasive cervical cancer. Very few studies have been conducted to examine the true prevalence of HPV infection in this population. Comparisons of cervical HPV infection and the type-specific distribution of HPV were performed between cancer-free Caribbean and US women. Results. The Caribbean population consisted of 212 women from Tobago and 99 women from Jamaica. The US population tested, consisted of 82 women from Pittsburgh. The majority of the US subjects was Caucasian, 74% (61/82) while 12% (10/82) and 13% (11/82) were African-American or other ethnic groups, respectively. The age-adjusted prevalence of any HPV infection among women from Tobago was 35%, while for Jamaica, it was 81% (p < 0.0001). The age-adjusted prevalence of HPV infection for Caribbean subjects was not statistically significantly different from the US (any HPV: 47% vs. 39%, p > 0.1; high-risk HPVs: 27% vs. 25%, p > 0.1); no difference was observed between US-Blacks and Jamaicans (any HPV: 92% vs. 81%, p > 0.1; high-risk HPV: 50% vs. 53%, p > 0.1). However, US-Whites had a lower age-adjusted prevalence of HPV infections compared to Jamaican subjects (any HPV: 29% vs. 81%, p < 0.0001; high-risk HPV: 20% vs. 53%, p < 0.001). Subjects from Jamaica, Tobago, and US-Blacks had a higher proportion of high-risk HPV infections (Tobago: 20%, Jamaica: 58%, US-Blacks: 40%) compared to US-Whites (15%). Similar observations were made for the presence of infections with multiple high-risk HPV types (Tobago: 12%, Jamaica: 43%, US-Blacks: 30%, US-Whites: 8%). Although we observed similar prevalence of HPV16 infections among Caribbean and US-White women, there was a distinct distribution of high-risk HPV types when comparisons were made between the ethnic groups. Conclusion. The higher prevalence of cervical HPV infections and multiple high-risk infections in Caribbean and US-Black women may contribute to the high incidence and prevalence of cervical cancer in these populations. Evaluation of a larger sample size is currently ongoing to confirm the distinct distribution of HPV types between ethnic groups.
UR - http://www.scopus.com/inward/record.url?scp=60349087416&partnerID=8YFLogxK
U2 - 10.1186/1750-9378-4-S1-S9
DO - 10.1186/1750-9378-4-S1-S9
M3 - Article
AN - SCOPUS:60349087416
SN - 1750-9378
VL - 4
JO - Infectious Agents and Cancer
JF - Infectious Agents and Cancer
IS - SUPPL. 1
M1 - S9
ER -