Comparisons between an oral and an intravenous method to demonstrate the in utero effects of ethanol in the monkey

S. Jacobson, P. Sehgal, R. Bronson

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The authors' goal has been to develop a non-human model which would replicate the abnormal behavioral and morphological effects of the fetal alcohol syndrome and which would also produce sufficient viable offspring. The methods of IV or oral ingestion were used to introduce ethanol into pregnant M. fascicularis monkeys. The IV method employs a catheter which is inserted into the external jugular while the oral method uses a semi-purified liquid diet containing 0-30% of the calories/day from ethanol. The authors have had only 1 live birth from the IV method and 3 other fetuses were still-born and one of the mothers died. From the oral ingestion method we have had 15 animals on the diet and the authors have had three live births, and one still birth. Associated with the IV approach is the method of catherization and maintenance of the catheter while the only difficulties in the oral method are to have the animals accept the diet and only 2 animals of the 17 the authors started with refused the diet. The authors believe the oral ingestion method is best for a long term chronic study while the IV infusion is best for a more acute study.

Original languageEnglish
Pages (from-to)253-258
Number of pages6
JournalNeurobehavioral Toxicology and Teratology
Volume2
Issue number3
StatePublished - 1980
Externally publishedYes

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