TY - JOUR
T1 - Comparison of vascular response to the everolimus-eluting stent versus the paclitaxel-eluting stent
T2 - Intravascular ultrasound results from the SPIRIT III trial
AU - Yamasaki, Masao
AU - Tsujino, Ichizo
AU - Lima-Filho, Moyses O.
AU - Ako, Junya
AU - Shimohama, Takao
AU - Hasegawa, Takao
AU - Sakurai, Ryota
AU - Sudhir, Krishnankutty
AU - Stone, Gregg W.
AU - Waseda, Katsuhisa
AU - Honda, Yasuhiro
AU - Fitzgerald, Peter J.
PY - 2012/10
Y1 - 2012/10
N2 - Aims: The purpose of this study was to investigate the vascular response of the everolimus-eluting stent (EES) compared with the paclitaxel-eluting stent (PES) using serial intravascular ultrasound (IVUS). Methods and results: Data were obtained from the SPIRIT III trial, a multicentre, 2:1 randomised, controlled study comparing EES and PES in de novo native coronary artery lesions. IVUS images were eligible for volumetric analysis at eight-month follow-up in 158 lesions (EES: 113, PES: 45). At eight months, EES had a smaller neointimal volume index (VI: mm3/mm) (EES: 0.4±0.4 vs. PES: 0.8±0.8 mm3/mm, p=0.002) and also a smaller % neointimal obstruction (EES: 7.1±6.7% vs. PES: 11.1±10.5%, p=0.005) compared with PES. While there was no significant change in vessel VI with EES, there was a significant increase in vessel VI in PES during eight-month follow-up (EES: 0.1±1.2 vs. PES: 1.2±0.8 mm3/mm, p=0.001). There were no statistical differences in the frequency of edge dissection or incomplete stent apposition between the two groups. Conclusions: Detailed IVUS analysis confirmed significantly less neointimal hyperplasia with EES compared with PES. While there was no increase in vessel volume with EES during the eight-month follow-up period, vessel enlargement was seen at the stented segment in PES.
AB - Aims: The purpose of this study was to investigate the vascular response of the everolimus-eluting stent (EES) compared with the paclitaxel-eluting stent (PES) using serial intravascular ultrasound (IVUS). Methods and results: Data were obtained from the SPIRIT III trial, a multicentre, 2:1 randomised, controlled study comparing EES and PES in de novo native coronary artery lesions. IVUS images were eligible for volumetric analysis at eight-month follow-up in 158 lesions (EES: 113, PES: 45). At eight months, EES had a smaller neointimal volume index (VI: mm3/mm) (EES: 0.4±0.4 vs. PES: 0.8±0.8 mm3/mm, p=0.002) and also a smaller % neointimal obstruction (EES: 7.1±6.7% vs. PES: 11.1±10.5%, p=0.005) compared with PES. While there was no significant change in vessel VI with EES, there was a significant increase in vessel VI in PES during eight-month follow-up (EES: 0.1±1.2 vs. PES: 1.2±0.8 mm3/mm, p=0.001). There were no statistical differences in the frequency of edge dissection or incomplete stent apposition between the two groups. Conclusions: Detailed IVUS analysis confirmed significantly less neointimal hyperplasia with EES compared with PES. While there was no increase in vessel volume with EES during the eight-month follow-up period, vessel enlargement was seen at the stented segment in PES.
KW - Coronary artery disease
KW - Everolimus-eluting stent
KW - Intravascular ultrasound
KW - Randomised trial
UR - http://www.scopus.com/inward/record.url?scp=84872134997&partnerID=8YFLogxK
U2 - 10.4244/EIJV8I6A112
DO - 10.4244/EIJV8I6A112
M3 - Article
C2 - 23086791
AN - SCOPUS:84872134997
SN - 1774-024X
VL - 8
SP - 724
EP - 731
JO - EuroIntervention
JF - EuroIntervention
IS - 6
ER -