Comparison of two PET radioligands for imaging extrastriatal dopamine transporters in human brain

Gene Jack Wang, Nora D. Volkow, Joanna S. Fowler, Yu Shin Ding, Jean Logan, S. John Galley, Robert R. MacGregor, Alfred P. Wolf

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

We compared the sensitivity of two dopamine transporter (DAT) ligands ([C-11]cocaine and [C-11]d-threo-methylphenidate) for measurement of extrastriatal DAT availability using positron emission tomography (PET) on separated groups of 10 age matched male volunteers (age range, 21-49 years). DAT availability was obtained using the ratio of the distribution volume in the region of interest to that in the cerebellum ( Bmax′ Kd′ + 1). DAT availability measured with [C-11] d-threo-methylphenidate was highest in basal ganglia, followed by thalamus > temporal insula, cingulate > orbitofrontal, frontal and occipital cortices. A similar ranking order for DAT availability was obtained with [C-11]cocaine. Specific binding ( Bmax′ Kd′) of [C-11]cocaine in thalamus was 25-33% that of basal ganglia and [C-11]d-threo-methylphenidate in thalamus was 11-13% that of basal ganglia. The regional measures with [C-11]cocaine were significantly correlated with those of [C-11]d-threo-methylphenidate (p < 0.0001). These results document extrastriatal binding in human brain with two different DAT ligands.

Original languageEnglish
Pages (from-to)PL187-PL191
JournalLife Sciences
Volume57
Issue number14
DOIs
StatePublished - 25 Aug 1995
Externally publishedYes

Keywords

  • [C-11]cocaine
  • [C-11]d-threo-methylphenidate
  • extrastriatal dopamine transporter
  • positron emission tomography

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