Comparison of two PET radioligands for imaging extrastriatal dopamine transporters in human brain

Gene Jack Wang; Nora D. Volkow; Joanna S. Fowler; Yu Shin Ding; Jean Logan; S. John Galley; Robert R. MacGregor; Alfred P. Wolf

doi:10.1016/0024-3205(95)02099-5

Comparison of two PET radioligands for imaging extrastriatal dopamine transporters in human brain

Gene Jack Wang, Nora D. Volkow, Joanna S. Fowler, Yu Shin Ding, Jean Logan, S. John Galley, Robert R. MacGregor, Alfred P. Wolf

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

We compared the sensitivity of two dopamine transporter (DAT) ligands ([C-11]cocaine and [C-11]d-threo-methylphenidate) for measurement of extrastriatal DAT availability using positron emission tomography (PET) on separated groups of 10 age matched male volunteers (age range, 21-49 years). DAT availability was obtained using the ratio of the distribution volume in the region of interest to that in the cerebellum ( B_max′ K_d′ + 1). DAT availability measured with [C-11] d-threo-methylphenidate was highest in basal ganglia, followed by thalamus > temporal insula, cingulate > orbitofrontal, frontal and occipital cortices. A similar ranking order for DAT availability was obtained with [C-11]cocaine. Specific binding ( B_max′ K_d′) of [C-11]cocaine in thalamus was 25-33% that of basal ganglia and [C-11]d-threo-methylphenidate in thalamus was 11-13% that of basal ganglia. The regional measures with [C-11]cocaine were significantly correlated with those of [C-11]d-threo-methylphenidate (p < 0.0001). These results document extrastriatal binding in human brain with two different DAT ligands.

Original language	English
Pages (from-to)	PL187-PL191
Journal	Life Sciences
Volume	57
Issue number	14
DOIs	https://doi.org/10.1016/0024-3205(95)02099-5
State	Published - 25 Aug 1995
Externally published	Yes

Keywords

[C-11]cocaine
[C-11]d-threo-methylphenidate
extrastriatal dopamine transporter
positron emission tomography

Access to Document

10.1016/0024-3205(95)02099-5

Cite this

@article{58aa13e12196481f8045deda019ac736,

title = "Comparison of two PET radioligands for imaging extrastriatal dopamine transporters in human brain",

abstract = "We compared the sensitivity of two dopamine transporter (DAT) ligands ([C-11]cocaine and [C-11]d-threo-methylphenidate) for measurement of extrastriatal DAT availability using positron emission tomography (PET) on separated groups of 10 age matched male volunteers (age range, 21-49 years). DAT availability was obtained using the ratio of the distribution volume in the region of interest to that in the cerebellum ( Bmax′ Kd′ + 1). DAT availability measured with [C-11] d-threo-methylphenidate was highest in basal ganglia, followed by thalamus > temporal insula, cingulate > orbitofrontal, frontal and occipital cortices. A similar ranking order for DAT availability was obtained with [C-11]cocaine. Specific binding ( Bmax′ Kd′) of [C-11]cocaine in thalamus was 25-33% that of basal ganglia and [C-11]d-threo-methylphenidate in thalamus was 11-13% that of basal ganglia. The regional measures with [C-11]cocaine were significantly correlated with those of [C-11]d-threo-methylphenidate (p < 0.0001). These results document extrastriatal binding in human brain with two different DAT ligands.",

keywords = "[C-11]cocaine, [C-11]d-threo-methylphenidate, extrastriatal dopamine transporter, positron emission tomography",

author = "Wang, {Gene Jack} and Volkow, {Nora D.} and Fowler, {Joanna S.} and Ding, {Yu Shin} and Jean Logan and Galley, {S. John} and MacGregor, {Robert R.} and Wolf, {Alfred P.}",

note = "Funding Information: This work was supportedb y NIDA Grant No. lROl-DAO9490-01 and by U.S. Department of Energy under contract DE-ACO2-76CHOOO16. The authors thank T. Johnson, P. King, N. Netusil, N. Pappas, C. Redvanly, D. Warner for their participation in various aspectso f this work.",

year = "1995",

month = aug,

day = "25",

doi = "10.1016/0024-3205(95)02099-5",

language = "English",

volume = "57",

pages = "PL187--PL191",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "14",

}

TY - JOUR

T1 - Comparison of two PET radioligands for imaging extrastriatal dopamine transporters in human brain

AU - Wang, Gene Jack

AU - Volkow, Nora D.

AU - Fowler, Joanna S.

AU - Ding, Yu Shin

AU - Logan, Jean

AU - Galley, S. John

AU - MacGregor, Robert R.

AU - Wolf, Alfred P.

N1 - Funding Information: This work was supportedb y NIDA Grant No. lROl-DAO9490-01 and by U.S. Department of Energy under contract DE-ACO2-76CHOOO16. The authors thank T. Johnson, P. King, N. Netusil, N. Pappas, C. Redvanly, D. Warner for their participation in various aspectso f this work.

PY - 1995/8/25

Y1 - 1995/8/25

N2 - We compared the sensitivity of two dopamine transporter (DAT) ligands ([C-11]cocaine and [C-11]d-threo-methylphenidate) for measurement of extrastriatal DAT availability using positron emission tomography (PET) on separated groups of 10 age matched male volunteers (age range, 21-49 years). DAT availability was obtained using the ratio of the distribution volume in the region of interest to that in the cerebellum ( Bmax′ Kd′ + 1). DAT availability measured with [C-11] d-threo-methylphenidate was highest in basal ganglia, followed by thalamus > temporal insula, cingulate > orbitofrontal, frontal and occipital cortices. A similar ranking order for DAT availability was obtained with [C-11]cocaine. Specific binding ( Bmax′ Kd′) of [C-11]cocaine in thalamus was 25-33% that of basal ganglia and [C-11]d-threo-methylphenidate in thalamus was 11-13% that of basal ganglia. The regional measures with [C-11]cocaine were significantly correlated with those of [C-11]d-threo-methylphenidate (p < 0.0001). These results document extrastriatal binding in human brain with two different DAT ligands.

AB - We compared the sensitivity of two dopamine transporter (DAT) ligands ([C-11]cocaine and [C-11]d-threo-methylphenidate) for measurement of extrastriatal DAT availability using positron emission tomography (PET) on separated groups of 10 age matched male volunteers (age range, 21-49 years). DAT availability was obtained using the ratio of the distribution volume in the region of interest to that in the cerebellum ( Bmax′ Kd′ + 1). DAT availability measured with [C-11] d-threo-methylphenidate was highest in basal ganglia, followed by thalamus > temporal insula, cingulate > orbitofrontal, frontal and occipital cortices. A similar ranking order for DAT availability was obtained with [C-11]cocaine. Specific binding ( Bmax′ Kd′) of [C-11]cocaine in thalamus was 25-33% that of basal ganglia and [C-11]d-threo-methylphenidate in thalamus was 11-13% that of basal ganglia. The regional measures with [C-11]cocaine were significantly correlated with those of [C-11]d-threo-methylphenidate (p < 0.0001). These results document extrastriatal binding in human brain with two different DAT ligands.

KW - [C-11]cocaine

KW - [C-11]d-threo-methylphenidate

KW - extrastriatal dopamine transporter

KW - positron emission tomography

UR - http://www.scopus.com/inward/record.url?scp=0028794755&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(95)02099-5

DO - 10.1016/0024-3205(95)02099-5

M3 - Article

C2 - 7564877

AN - SCOPUS:0028794755

SN - 0024-3205

VL - 57

SP - PL187-PL191

JO - Life Sciences

JF - Life Sciences

IS - 14

ER -

Comparison of two PET radioligands for imaging extrastriatal dopamine transporters in human brain

Abstract

Keywords

Access to Document

Fingerprint

Cite this