Comparison of the binding of the irreversible monoamine oxidase tracers, [11C]clorgyline and [11C]l-deprenyl in brain and peripheral organs in humans

Joanna S. Fowler; Jean Logan; Gene Jack Wang; Nora D. Volkow; Frank Telang; Yu Shin Ding; Colleen Shea; Victor Garza; Youwen Xu; Zizhong Li; David Alexoff; Paul Vaska; Richard Ferrieri; David Schlyer; Wei Zhu; S. John Gatley

doi:10.1016/j.nucmedbio.2003.10.003

Comparison of the binding of the irreversible monoamine oxidase tracers, [¹¹C]clorgyline and [¹¹C]l-deprenyl in brain and peripheral organs in humans

Joanna S. Fowler, Jean Logan, Gene Jack Wang, Nora D. Volkow, Frank Telang, Yu Shin Ding, Colleen Shea, Victor Garza, Youwen Xu, Zizhong Li, David Alexoff, Paul Vaska, Richard Ferrieri, David Schlyer, Wei Zhu, S. John Gatley

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

The monoamine oxidase A and B (MAO A and B) radiotracers [ ¹¹C]clorgyline (CLG) and [¹¹C]L-deprenyl (DEP) and their deuterium labeled counterparts (CLG-D and DEP-D) were compared to determine whether their distribution and kinetics in humans are consistent with their physical, chemical and pharmacological properties and the reported ratios of MAO A:MAO B in post-mortem human tissues. Irreversible binding was consistently higher for DEP in brain, heart, kidneys and spleen but not lung where CLG >DEP and not in thyroid where there is no DEP binding. The generally higher DEP binding is consistent with its higher enzyme affinity and larger free fraction in plasma while differences in regional distribution for CLG and DEP in brain, heart, thyroid and lungs are consistent with different relative ratios of MAO A and B in humans.

Original language	English
Pages (from-to)	313-319
Number of pages	7
Journal	Nuclear Medicine and Biology
Volume	31
Issue number	3
DOIs	https://doi.org/10.1016/j.nucmedbio.2003.10.003
State	Published - Apr 2004
Externally published	Yes

Keywords

Brain
Monoamine oxidase A and B
Peripheral organs

Access to Document

10.1016/j.nucmedbio.2003.10.003

Cite this

Fowler, J. S., Logan, J., Wang, G. J., Volkow, N. D., Telang, F., Ding, Y. S., Shea, C., Garza, V., Xu, Y., Li, Z., Alexoff, D., Vaska, P., Ferrieri, R., Schlyer, D., Zhu, W., & Gatley, S. J. (2004). Comparison of the binding of the irreversible monoamine oxidase tracers, [¹¹C]clorgyline and [¹¹C]l-deprenyl in brain and peripheral organs in humans. Nuclear Medicine and Biology, 31(3), 313-319. https://doi.org/10.1016/j.nucmedbio.2003.10.003

@article{2058337ede7745179e649c13021c0b0e,

title = "Comparison of the binding of the irreversible monoamine oxidase tracers, [11C]clorgyline and [11C]l-deprenyl in brain and peripheral organs in humans",

abstract = "The monoamine oxidase A and B (MAO A and B) radiotracers [ 11C]clorgyline (CLG) and [11C]L-deprenyl (DEP) and their deuterium labeled counterparts (CLG-D and DEP-D) were compared to determine whether their distribution and kinetics in humans are consistent with their physical, chemical and pharmacological properties and the reported ratios of MAO A:MAO B in post-mortem human tissues. Irreversible binding was consistently higher for DEP in brain, heart, kidneys and spleen but not lung where CLG >DEP and not in thyroid where there is no DEP binding. The generally higher DEP binding is consistent with its higher enzyme affinity and larger free fraction in plasma while differences in regional distribution for CLG and DEP in brain, heart, thyroid and lungs are consistent with different relative ratios of MAO A and B in humans.",

keywords = "Brain, Monoamine oxidase A and B, Peripheral organs",

author = "Fowler, {Joanna S.} and Jean Logan and Wang, {Gene Jack} and Volkow, {Nora D.} and Frank Telang and Ding, {Yu Shin} and Colleen Shea and Victor Garza and Youwen Xu and Zizhong Li and David Alexoff and Paul Vaska and Richard Ferrieri and David Schlyer and Wei Zhu and Gatley, {S. John}",

note = "Funding Information: This work was carried out at Brookhaven National Laboratory under contract DE-AC02-98CH10886 with the U. S. Department of Energy and supported by its Office of Biological and Environmental Research and by the National Institute for Biomedical Imaging and Bioengineering (EB002630), the National Institute on Drug Abuse (DA 7092-01& DA00280) and the Office of National Drug Control Policy. We are grateful to Michael Schueller for cyclotron operations and to Karen Apelskog for protocol coordination. We are also grateful to the people who volunteered for these studies.",

year = "2004",

month = apr,

doi = "10.1016/j.nucmedbio.2003.10.003",

language = "English",

volume = "31",

pages = "313--319",

journal = "Nuclear Medicine and Biology",

issn = "0969-8051",

publisher = "Elsevier Inc.",

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Fowler, JS, Logan, J, Wang, GJ, Volkow, ND, Telang, F, Ding, YS, Shea, C, Garza, V, Xu, Y, Li, Z, Alexoff, D, Vaska, P, Ferrieri, R, Schlyer, D, Zhu, W & Gatley, SJ 2004, 'Comparison of the binding of the irreversible monoamine oxidase tracers, [¹¹C]clorgyline and [¹¹C]l-deprenyl in brain and peripheral organs in humans', Nuclear Medicine and Biology, vol. 31, no. 3, pp. 313-319. https://doi.org/10.1016/j.nucmedbio.2003.10.003

TY - JOUR

T1 - Comparison of the binding of the irreversible monoamine oxidase tracers, [11C]clorgyline and [11C]l-deprenyl in brain and peripheral organs in humans

AU - Fowler, Joanna S.

AU - Logan, Jean

AU - Wang, Gene Jack

AU - Volkow, Nora D.

AU - Telang, Frank

AU - Ding, Yu Shin

AU - Shea, Colleen

AU - Garza, Victor

AU - Xu, Youwen

AU - Li, Zizhong

AU - Alexoff, David

AU - Vaska, Paul

AU - Ferrieri, Richard

AU - Schlyer, David

AU - Zhu, Wei

AU - Gatley, S. John

N1 - Funding Information: This work was carried out at Brookhaven National Laboratory under contract DE-AC02-98CH10886 with the U. S. Department of Energy and supported by its Office of Biological and Environmental Research and by the National Institute for Biomedical Imaging and Bioengineering (EB002630), the National Institute on Drug Abuse (DA 7092-01& DA00280) and the Office of National Drug Control Policy. We are grateful to Michael Schueller for cyclotron operations and to Karen Apelskog for protocol coordination. We are also grateful to the people who volunteered for these studies.

PY - 2004/4

Y1 - 2004/4

N2 - The monoamine oxidase A and B (MAO A and B) radiotracers [ 11C]clorgyline (CLG) and [11C]L-deprenyl (DEP) and their deuterium labeled counterparts (CLG-D and DEP-D) were compared to determine whether their distribution and kinetics in humans are consistent with their physical, chemical and pharmacological properties and the reported ratios of MAO A:MAO B in post-mortem human tissues. Irreversible binding was consistently higher for DEP in brain, heart, kidneys and spleen but not lung where CLG >DEP and not in thyroid where there is no DEP binding. The generally higher DEP binding is consistent with its higher enzyme affinity and larger free fraction in plasma while differences in regional distribution for CLG and DEP in brain, heart, thyroid and lungs are consistent with different relative ratios of MAO A and B in humans.

AB - The monoamine oxidase A and B (MAO A and B) radiotracers [ 11C]clorgyline (CLG) and [11C]L-deprenyl (DEP) and their deuterium labeled counterparts (CLG-D and DEP-D) were compared to determine whether their distribution and kinetics in humans are consistent with their physical, chemical and pharmacological properties and the reported ratios of MAO A:MAO B in post-mortem human tissues. Irreversible binding was consistently higher for DEP in brain, heart, kidneys and spleen but not lung where CLG >DEP and not in thyroid where there is no DEP binding. The generally higher DEP binding is consistent with its higher enzyme affinity and larger free fraction in plasma while differences in regional distribution for CLG and DEP in brain, heart, thyroid and lungs are consistent with different relative ratios of MAO A and B in humans.

KW - Brain

KW - Monoamine oxidase A and B

KW - Peripheral organs

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U2 - 10.1016/j.nucmedbio.2003.10.003

DO - 10.1016/j.nucmedbio.2003.10.003

M3 - Article

C2 - 15028243

AN - SCOPUS:12144289768

SN - 0969-8051

VL - 31

SP - 313

EP - 319

JO - Nuclear Medicine and Biology

JF - Nuclear Medicine and Biology

IS - 3