Comparison of polyfluoroalkyl compound concentrations in maternal serum and amniotic fluid: A pilot study

Cheryl R. Stein, Mary S. Wolff, Antonia M. Calafat, Kayoko Kato, Stephanie M. Engel

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

The extent to which polyfluoroalkyl compounds (PFCs) are detectable in amniotic fluid is unknown. Using paired samples from 28 women, we compared the concentration of 8 PFCs measured in serum, the standard matrix for assessing human exposure, amniotic fluid from routine amniocentesis, and urine. Perfluorooctanoate (PFOA), perfluorononanoate (PFNA), perfluorooctane sulfonate (PFOS), and perfluorohexane sulfonate (PFHxS) were detected in all maternal serum samples. The number of amniotic fluid samples with detectable concentrations differed by PFC (PFOA n= 24; PFNA n= 10; PFOS n= 9; PFHxS n= 4). The correlation coefficient between maternal serum and amniotic PFC levels varied considerably by PFC (PFOA ρ= 0.64, p< 0.001; PFNA ρ= 0.05, p= 0.9; PFOS ρ= 0.76, p= 0.01; PFHxS ρ= 0.80, p= 0.2). Using linear regression, PFOA appeared to be commonly detected in amniotic fluid if the serum concentration exceeded approximately 1.5. ng/mL whereas PFOS was rarely detected in amniotic fluid until the serum concentration was about 5.5. ng/mL. No PFCs were detected in urine.

Original languageEnglish
Pages (from-to)312-316
Number of pages5
JournalReproductive Toxicology
Volume34
Issue number3
DOIs
StatePublished - Nov 2012

Keywords

  • Amniotic fluid
  • Fluorocarbons
  • Maternal serum
  • Perfluorooctane sulfonate
  • Perfluorooctanoate
  • Pregnancy

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