Abstract
48 adult patients ASA Physical Status I or II participated in a double blind study comparing midazolam with thiopental for induction of anesthesia. 24 patients were premedicated with Innovar® 0.02 ml/kg I.M. and atropine sulfate 0.006 mg/kg I.M.; the rest received no premedication. In unpremedicated patients induction was unsatisfactory with midazolam in doses of 0.15 mg/kg to 0.225 mg/kg. In premedicated patients satisfactory induction was achieved with midazolam 0.175 mg/kg. In unpremedicated patients induced with midazolam, eyelid reflex was lost significantly earlier than the response to commands. Compared to thiopental, induction was slower and recovery time more prolonged with midazolam. The incidence of venous irritation was similar in patients receiving midazolam or pentothal. Midazolam is a superior alternative to diazepam for induction of anesthesia.
| Original language | English |
|---|---|
| Pages (from-to) | 21-27 |
| Number of pages | 7 |
| Journal | Anesthesiology Review |
| Volume | 7 |
| Issue number | 12 |
| State | Published - 1980 |