Comparison of mammalian VIP bioactivities in dispersed acini from guinea pig pancreas

Jean Pierre Raufman, John Eng, B. H. Du, Eugene Straus, Rosalyn S. Yalow

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Mammalian VIP is identical in pig, cow, human, rat, dog and goat but differs in the guinea pig (GP) in positions 5, 9, 19, and 26. We now demonstrate that GP, goat, rat and synthetic mammalian VIP are indistinguishable in their inhibition of binding of 125I-labelled synthetic VIP to dispersed acini from GP pancreas and that GP, pig, dog, goat and synthetic VIP are also similar in their efficacy and potency in stimulating amylase release from these acini. Thus in spite of the differences in amino acid sequence, GP VIP appears to have full biologic potency in its action on dispersed acini from GP pancreas.

Original languageEnglish
Pages (from-to)93-97
Number of pages5
JournalRegulatory Peptides
Volume14
Issue number1
DOIs
StatePublished - Mar 1986
Externally publishedYes

Keywords

  • acini
  • guinea pig
  • mammalian VIP
  • pancreas

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