@inbook{2066eae71317471785a8f63b99e151d5,
title = "Comparison of K+ Channel Families",
abstract = "K+ channels enable potassium to flow across the membrane with great selectivity. There are four K+ channel families: voltage-gated K (Kv), calcium-activated (KCa), inwardly rectifying K (Kir), and two-pore domain potassium (K2P) channels. All four K+ channels are formed by subunits assembling into a classic tetrameric (4x1P = 4P for the Kv, KCa, and Kir channels) or tetramer-like (2x2P = 4P for the K2P channels) architecture. These subunits can either be the same (homomers) or different (heteromers), conferring great diversity to these channels. They share a highly conserved selectivity filter within the pore but show different gating mechanisms adapted for their function. K+ channels play essential roles in controlling neuronal excitability by shaping action potentials, influencing the resting membrane potential, and responding to diverse physicochemical stimuli, such as a voltage change (Kv), intracellular calcium oscillations (KCa), cellular mediators (Kir), or temperature (K2P).",
keywords = "Calcium-activated, Conductivity, Gating, Inwardly rectifying K, Ion channel, Potassium channel, Selectivity, Two-pore domain potassium, Voltage-gated K",
author = "Jaume Taura and Kircher, {Daniel M.} and Isabel Gameiro-Ros and Slesinger, {Paul A.}",
note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG.",
year = "2021",
doi = "10.1007/164_2021_460",
language = "English",
series = "Handbook of Experimental Pharmacology",
publisher = "Springer Science and Business Media Deutschland GmbH",
pages = "1--49",
booktitle = "Handbook of Experimental Pharmacology",
address = "Germany",
}