Comparison of gene expression of the dopamine D-2 receptor and DARPP-32 in rat brain, pituitary and adrenal gland

Martin Schalling; Åke Dagerlind; Menek Goldstein; Michelle Ehrlich; Paul Greengard; Tomas Hökfelt

doi:10.1016/0922-4106(90)90012-M

Comparison of gene expression of the dopamine D-2 receptor and DARPP-32 in rat brain, pituitary and adrenal gland

Martin Schalling, Åke Dagerlind, Menek Goldstein, Michelle Ehrlich, Paul Greengard, Tomas Hökfelt

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

In situ hybridization histochemistry was used to compare the distribution of dopamine D-2 receptor mRNA and DARPP-32 mRNA in rat brain, pituitary and adrenal gland. In many regions such as the caudate nucleus, nucleus accumbens and olfactory tubercle, there was an excellent correlation with dopamine receptor binding studies, whereas in some discrete brain regions mismatches were observed.

Original language	English
Pages (from-to)	277-281
Number of pages	5
Journal	European Journal of Pharmacology: Molecular Pharmacology
Volume	188
Issue number	4-5
DOIs	https://doi.org/10.1016/0922-4106(90)90012-M
State	Published - 25 Apr 1990
Externally published	Yes

Keywords

Caudate nucleus
Dopamine D-1 receptors
Hybridization (in situ)
Nucleus accumbens
Substantia nigra
Tyrosine hydroxylase

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10.1016/0922-4106(90)90012-M

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title = "Comparison of gene expression of the dopamine D-2 receptor and DARPP-32 in rat brain, pituitary and adrenal gland",

abstract = "In situ hybridization histochemistry was used to compare the distribution of dopamine D-2 receptor mRNA and DARPP-32 mRNA in rat brain, pituitary and adrenal gland. In many regions such as the caudate nucleus, nucleus accumbens and olfactory tubercle, there was an excellent correlation with dopamine receptor binding studies, whereas in some discrete brain regions mismatches were observed.",

keywords = "Caudate nucleus, Dopamine D-1 receptors, Hybridization (in situ), Nucleus accumbens, Substantia nigra, Tyrosine hydroxylase",

author = "Martin Schalling and {\AA}ke Dagerlind and Menek Goldstein and Michelle Ehrlich and Paul Greengard and Tomas H{\"o}kfelt",

note = "Funding Information: This study was supported by the NIMH (MH 43230-02). (MH NS 31862), U.S.P.H.S. Grants (MH 40899, MH 00606). the Swedish MRC (04X-2887). the American Parkinson Dis* ease Association, and Marianne and Marcus Waltenbergs Stif-telse, We thank Ms. Katarina Friberg for expert technical assistance.",

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doi = "10.1016/0922-4106(90)90012-M",

language = "English",

volume = "188",

pages = "277--281",

journal = "European Journal of Pharmacology: Molecular Pharmacology",

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T1 - Comparison of gene expression of the dopamine D-2 receptor and DARPP-32 in rat brain, pituitary and adrenal gland

AU - Schalling, Martin

AU - Dagerlind, Åke

AU - Goldstein, Menek

AU - Ehrlich, Michelle

AU - Greengard, Paul

AU - Hökfelt, Tomas

N1 - Funding Information: This study was supported by the NIMH (MH 43230-02). (MH NS 31862), U.S.P.H.S. Grants (MH 40899, MH 00606). the Swedish MRC (04X-2887). the American Parkinson Dis* ease Association, and Marianne and Marcus Waltenbergs Stif-telse, We thank Ms. Katarina Friberg for expert technical assistance.

PY - 1990/4/25

Y1 - 1990/4/25

N2 - In situ hybridization histochemistry was used to compare the distribution of dopamine D-2 receptor mRNA and DARPP-32 mRNA in rat brain, pituitary and adrenal gland. In many regions such as the caudate nucleus, nucleus accumbens and olfactory tubercle, there was an excellent correlation with dopamine receptor binding studies, whereas in some discrete brain regions mismatches were observed.

AB - In situ hybridization histochemistry was used to compare the distribution of dopamine D-2 receptor mRNA and DARPP-32 mRNA in rat brain, pituitary and adrenal gland. In many regions such as the caudate nucleus, nucleus accumbens and olfactory tubercle, there was an excellent correlation with dopamine receptor binding studies, whereas in some discrete brain regions mismatches were observed.

KW - Caudate nucleus

KW - Dopamine D-1 receptors

KW - Hybridization (in situ)

KW - Nucleus accumbens

KW - Substantia nigra

KW - Tyrosine hydroxylase

UR - https://www.scopus.com/pages/publications/0025342822

U2 - 10.1016/0922-4106(90)90012-M

DO - 10.1016/0922-4106(90)90012-M

M3 - Article

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VL - 188

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JO - European Journal of Pharmacology: Molecular Pharmacology

JF - European Journal of Pharmacology: Molecular Pharmacology

IS - 4-5

ER -

Comparison of gene expression of the dopamine D-2 receptor and DARPP-32 in rat brain, pituitary and adrenal gland

Abstract

Keywords

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