Comparison of differences in outcome after percutaneous coronary intervention in men versus women <40 years of age

Alexandra J. Lansky, Roxana Mehran, George Dangas, Ecaterina Cristea, Kazuyuki Shirai, Ricardo Costa, Costantino Costantini, Yoshihiro Tsuchiya, Stephane Carlier, Gary Mintz, Yves Cottin, Gregg Stone, Jeffrey Moses, Martin B. Leon

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

We evaluated the outcomes of 177 consecutive patients (43 women, 134 men) <40 years of age with premature atherosclerosis who underwent percutaneous coronary intervention. Women were younger, had more diabetes mellitus (37% vs 10%; p <0.001), but less hyperlipidemia (58% vs 75%; p <0.001) compared with men. In-hospital vascular complications and 1-year mortality rate or Q-wave myocardial infarction (7.9% vs 0.08%, p <0.01) were higher in women. By multivariable regression analysis, female gender was the only independent predictor of vascular complications (odds ratio, 14.1; 95% confidence intervals, 1.59 to 125, p = 0.01) and of 1-year mortality rate or nonfatal myocardial infarction (odds ratio, 12.5; 95% confidence interval, 1.14 to 111, p = 0.03). Women with premature coronary disease had a distinctive risk factor profile relative to men, with a predominance of diabetes and hypercholesterolemia, and were at higher risk of developing vascular and ischemic complications after percutaneous coronary intervention, warranting aggressive risk factor modification and vigilance in this population.

Original languageEnglish
Pages (from-to)916-919
Number of pages4
JournalAmerican Journal of Cardiology
Volume93
Issue number7
DOIs
StatePublished - 1 Apr 2004
Externally publishedYes

Fingerprint

Dive into the research topics of 'Comparison of differences in outcome after percutaneous coronary intervention in men versus women <40 years of age'. Together they form a unique fingerprint.

Cite this